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J. Dairy Sci. 2009. 92:4676-4682. doi:10.3168/jds.2008-1965
© 2009 American Dairy Science Association ®
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Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids

A. Schennink1,2, W. M. Stoop2, M. H. P. W. Visker, J. J. van der Poel, H. Bovenhuis and J. A. M. van Arendonk

Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, the Netherlands

1 Corresponding author: aschennink{at}ucdavis.edu

We present the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in long-chain milk fatty acids. Milk-fat composition phenotypes were available on 1,905 Dutch Holstein-Friesian cows. A total of 849 cows and their 7 sires were genotyped for 1,341 single nucleotide polymorphisms across all Bos taurus autosomes (BTA). We detected significant QTL on BTA14, BTA15, and BTA16: for C18:1 cis-9, C18:1 cis-12, C18:2 cis-9,12, CLA cis-9,trans-11, C18:3 cis-9,12,15, the C18 index, the total index, total saturated fatty acids, total unsaturated fatty acids (UFA), and the ratio of saturated fatty acids:unsaturated fatty acids on BTA14; for C18:1 trans fatty acids on BTA15; and for the C18 and CLA indices on BTA16. The QTL explained 3 to 19% of the phenotypic variance. Suggestive QTL were found on 16 other chromosomes. The diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism on BTA14, which is known to influence fatty acid composition, most likely explains the QTL that was detected on BTA14.

Key Words: fatty acid • quantitative trait locus • dairy cow • diacylglycerol acyltransferase 1


Related articles in JDS:

Genome-wide scan for bovine milk-fat composition. I. Quantitative trait loci for short- and medium-chain fatty acids
W. M. Stoop, A. Schennink, M. H. P. W. Visker, E. Mullaart, J. A. M. van Arendonk, and H. Bovenhuis
JDS 2009 92: 4664-4675. [Abstract] [Full Text]  





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