JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Dairy Sci. 2009. 92:4018-4022. doi:10.3168/jds.2008-1536
© 2009 American Dairy Science Association ®
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Interpretive Summary
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Goertz, I.
Right arrow Articles by Erhardt, G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goertz, I.
Right arrow Articles by Erhardt, G.

Association between single nucleotide polymorphisms in the CXCR1 gene and somatic cell score in Holstein dairy cattle

I. Goertz*, C. Baes{dagger}, C. Weimann*, N. Reinsch{dagger} and G. Erhardt*,1

* Department of Animal Breeding and Genetics, Justus-Liebig-University, 35390 Giessen, Germany
{dagger} Research Institute for Biology of Farm Animals, 18196 Dummerstorf, Germany

1 Corresponding author: Georg.Erhardt{at}agrar.uni-giessen.de

In addition to its position in a quantitative trait locus for somatic cell score (SCS) and its function in the immune response, the CXCR1 chemokine receptor gene located on Bos taurus autosome 2 is an auspicious candidate gene for udder health in dairy cattle. An association analysis was conducted in the German Holstein-Friesian population to test the association between the single nucleotide polymorphism (SNP) at position +777 within the CXCR1 gene and the SNP at position –1768 in the 5' upstream region of this gene (rs41255711) and the indicator trait SCS by using a granddaughter design. Data were analyzed for 3 families, with a total of 749 genotyped bulls and an extended pedigree of 8,071 animals from the national German bovine genome mapping project. Variance component estimation was used to determine the source of phenotypic variation in the chromosomal area of interest. A 20-cM window surrounding the 2 SNP in the CXCR1 gene was examined. Although the percentage of variance caused by the putative quantitative trait locus in the area studied was relatively large (12 and 11%, respectively), no statistically significant association of the SNP CXCR1+777 or CXCR1–1768 with SCS was found. These results contradict previously published studies.

Key Words: somatic cell score • dairy cow • CXCR1






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the American Dairy Science Association ®.