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Fine Mapping of Quantitative Trait Loci on Bovine Chromosome 6 Affecting Calving Difficulty

H. G. Olsen^*,1, T. H. E. Meuwissen^*,, H. Nilsen^*, M. Svendsen and S. Lien^*,

^* Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N-1432 Ås, Norway
Centre for Integrative Genetics, Norwegian University of Life Sciences, N-1432 Ås, Norway
Geno Breeding and AI Organisation, N-1432 Ås, Norway

¹ Corresponding author: hanne-gro.olsen{at}umb.no

Calving difficulty is an economically and ethically important trait for dairy cattle breeding. The aim of the present paper was to refine the position of a previously detected quantitative trait locus (QTL) affecting calving difficulty (direct effect) in Norwegian Red dairy cows. A granddaughter design consisting of 18 elite sire families and a total of 713 sons was genotyped for 154 markers spanning the QTL region, and the trait data were analyzed by using a combined linkage and linkage disequilibrium approach. A highly significant QTL was detected in a 150-kb interval between the markers LAP3_281 and BTA-114677. Additionally, there were some indications of a second QTL between the markers BTA-75776 and BTA-75780 located less than 500 kb apart. Several candidate genes may be identified close to these QTL. Of these, a cluster of genes expected to affect bone and cartilage formation may be of particular interest for follow-up studies.

Key Words: calving difficulty • cattle • fine mapping • linkage disequilibrium

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