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Modeling Nutrient Fluxes and Plasma Ketone Bodies in Periparturient Cows

Department of Animal and Avian Sciences, University of Maryland, College Park 20742

¹ Corresponding author: rkohn{at}umd.edu

A mechanistic model was developed to study the interrelationship between glucose and lipid metabolism in periparturient cows. The driving variables were dry matter intake, feed composition, calf birth weight, milk production, and milk components. The response variables were body fat content and concentrations of plasma glucose, glycerol, nonesterified fatty acids (NEFA), and total ketone bodies (KB). Fetal growth and milk synthesis were assigned the highest priority for glucose demand in the model. The rate of fat mobilization was expressed as a function of glucose deficiency. The model assumed first-order kinetics for utilization of NEFA and KB. Model prediction errors were 19, 43, 48, and 36% of mean predictions for glucose, glycerol, NEFA, and KB, respectively. A linear bias was observed in KB and glycerol predictions. The model may be useful for understanding and explaining ketosis development.

Key Words: mechanistic model • glucose metabolism • lipid metabolism • periparturient cow

This article has been cited by other articles:

				J. Guo, R. R. Peters, and R. A. Kohn Evaluation of a Mechanistic Model of Glucose and Lipid Metabolism in Periparturient Cows J Dairy Sci, November 1, 2008; 91(11): 4293 - 4300. [Abstract] [Full Text] [PDF]