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Bovine Milk Glycome

N. Tao^*, E. J. DePeters, S. Freeman, J. B. German, R. Grimm and C. B. Lebrilla^*,1

^* Department of Chemistry and Biochemistry (School of Medicine),
Department of Animal Science, and
Department of Food Science Technology, University of California, Davis 95616
Agilent Technologies Inc., Santa Clara, CA 95052-8059

¹ Corresponding author: cblebrilla{at}ucdavis.edu

Bovine milk oligosaccharides have several potentially important biological activities including the prevention of pathogen binding to the intestinal epithelial and as nutrients for beneficial bacteria. It has been suggested that milk oligosaccharides are an important source of complex carbohydrates as supplements for the food and the pharmaceutical industries. However, only a small number of structures of bovine milk oligosaccharides (bMO) are known. There have been no systematic studies on bMO. High-performance mass spectrometry and separation methods are used to evaluate bMO, and nearly 40 oligosaccharides are present in bovine milk. Bovine milk oligosaccharides are composed of shorter oligomeric chains than are those in human milk. They are significantly more anionic with nearly 70%, measured abundances, being sialylated. Additionally, bMO are built not only on the lactose core (as are nearly all human milk oligosaccharides), but also on lactose amines. Sialic acid residues include both N-acetyl and N-glycolylneuraminic acid, although the former is significantly more abundant.

Key Words: oligosaccharide • bovine milk • high-performance liquid chromatography • mass spectrometry

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				N. Tao, E. J. DePeters, J. B. German, R. Grimm, and C. B. Lebrilla Variations in bovine milk oligosaccharides during early and middle lactation stages analyzed by high-performance liquid chromatography-chip/mass spectrometry J Dairy Sci, July 1, 2009; 92(7): 2991 - 3001. [Abstract] [Full Text] [PDF]