HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Interpretive Summary Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hinger, M. Articles by Erhardt, G. Search for Related Content PubMed PubMed Citation Articles by Hinger, M. Articles by Erhardt, G.

Short Communication: Association Analysis of Microsatellites and Mycobacterium avium Subspecies paratuberculosis Antibody Response in German Holsteins

M. Hinger^*, H. Brandt^*, S. Horner and G. Erhardt^*,1

^* Justus-Liebig University, Department of Animal Breeding and Genetics, Giessen, Germany
Animal Health Service of Thuringia, Bad Langensalza, Germany

¹ Corresponding author: Georg.Erhardt{at}agrar.uni-giessen.de

Paratuberculosis in ruminants is characterized by chronic granulomatous enteritis, resulting in persistent diarrhea and progressive wasting of cattle infected with Mycobacterium avium ssp. paratuberculosis (MAP). The disease occurs worldwide with high frequency, leading to growing economic losses in beef and dairy industries. The objective of this study was to investigate associations of microsatellites (BMC9006, BB704, BB705, BB717, BB719, BMS1617, BB702, and BOBT24) located near or within candidate genes involved in response mechanisms to paratuberculosis. Pedigree information existed for 4,686 German Holstein cows that had routinely been screened for MAP status using commercially available serum antibody ELISA test. The immunoglobulin G cutoff level was used to classify all animals as positive or negative for paratuberculosis. A total of 594 (12.7%) cows tested positive for paratuberculosis. The control group comprised 585 animals testing negative for MAP. Microsatellite BMC9006 had only 3 alleles (2 of which occurred at very low frequencies in the present data set) and was therefore not informative; the remaining microsatellites showed 3 to 12 alleles. Fisher’s exact and ² tests revealed no significant differences in microsatellite allele frequencies between the 2 groups of German Holstein cows testing positive or negative for paratuberculosis.

Key Words: paratuberculosis • microsatellite • susceptibility • German Holstein

This article has been cited by other articles:

				M. Hinger, H. Brandt, and G. Erhardt Heritability Estimates for Antibody Response to Mycobacterium avium subspecies paratuberculosis in German Holstein Cattle J Dairy Sci, August 1, 2008; 91(8): 3237 - 3244. [Abstract] [Full Text] [PDF]