| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington 05405
2 Department of Animal Sciences, University of Illinois, Urbana 61801
Corresponding author: Thomas B. McFadden; e-mail: tmcfadde{at}zoo.uvm.edu.
Suppressors of cytokine signaling (SOCS) are induced by prolactin and act through negative feedback to inhibit cytokine signaling. We hypothesized that lower prolactin concentrations in cows exposed to short-day photoperiod (SD; 8 h light:16 h dark) lead to decreased expression of SOCS, which mediate the effects of SD on mammary proliferation during the dry period. Multiparous Holstein cows were dried off 60 d before expected calving and were assigned to long-day photoperiod (LD; 16 h light:8 h dark) or SD during the dry period. Mammary biopsies were obtained at –40, –20, –10, and +10 d relative to expected calving, and expression of SOCS-1, SOCS-2, SOCS-3, and cytokine-inducible SH2-containing protein (CIS) mRNA was assessed by real-time, quantitative, reverse transcription-PCR. Expression of all SOCS increased over time and expression of SOCS-3, SOCS-2, and CIS mRNA was lower in mammary gland of SD cows. These data suggest that lower SOCS expression in cows exposed to SD during the dry period may enhance prolactin signaling to the mammary gland, thereby augmenting mammary development during pregnancy and milk production in the subsequent lactation. Changes in SOCS expression during pregnancy and lactation imply that SOCS may regulate mammary gland development and function in dairy cows.
Key Words: photoperiod • suppressors of cytokine signaling • prolactin • mammary gland
Abbreviation key: CIS = cytokine-inducible SH2-containing protein, LD = long-day photoperiod, PRL = prolactin, PRL-R = prolactin receptor, SD = short-day photoperiod, SOCS = suppressors of cytokine signaling.
This article has been cited by other articles:
|
|
 |
|
  B. C. do Amaral, E. E. Connor, S. Tao, J. Hayen, J. Bubolz, and G. E. Dahl Heat-stress abatement during the dry period: Does cooling improve transition into lactation? J Dairy Sci, December 1, 2009; 92(12): 5988 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Morrissey, A. W. N. Cameron, and A. J. Tilbrook Artificial Lighting During Winter Increases Milk Yield in Dairy Ewes J Dairy Sci, November 1, 2008; 91(11): 4238 - 4243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Velasco, E. D. Reid, K. K. Fried, T. F. Gressley, R. L. Wallace, and G. E. Dahl Short-Day Photoperiod Increases Milk Yield in Cows with a Reduced Dry Period Length J Dairy Sci, September 1, 2008; 91(9): 3467 - 3473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Piantoni, M. Bionaz, D. E. Graugnard, K. M. Daniels, R. M. Akers, and J. J. Loor Gene Expression Ratio Stability Evaluation in Prepubertal Bovine Mammary Tissue from Calves Fed Different Milk Replacers Reveals Novel Internal Controls for Quantitative Polymerase Chain Reaction J. Nutr., June 1, 2008; 138(6): 1158 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Winkelman, M. C. Lucy, T. H. Elsasser, J. L. Pate, and C. K. Reynolds Short Communication: Suppressor of Cytokine Signaling-2 mRNA Increases After Parturition in the Liver of Dairy Cows J Dairy Sci, March 1, 2008; 91(3): 1080 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Wall and T. B. McFadden Use it or lose it: Enhancing milk production efficiency by frequent milking of dairy cows J Anim Sci, March 1, 2008; 86(13_suppl): 27 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Dahl Effects of short day photoperiod on prolactin signaling in dry cows: A common mechanism among tissues and environments? J Anim Sci, March 1, 2008; 86(13_suppl): 10 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Wall, H. M. Crawford, S. E. Ellis, G. E. Dahl, and T. B. McFadden Mammary Response to Exogenous Prolactin or Frequent Milking During Early Lactation in Dairy Cows J Dairy Sci, December 1, 2006; 89(12): 4640 - 4648. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
