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Bioavailability of Vitamin D from Fortified Process Cheese and Effects on Vitamin D Status in the Elderly^*

¹ Dairy Science Department,
² Exercise Physiology Laboratory, and
³ Ethel Austin Martin Endowed Program in Human Nutrition, South Dakota State University, Brookings 57007
⁴ Department of Pediatrics, Medical University of South Carolina, Charleston 29425

Corresponding author: V. V. Mistry; e-mail: vikram.mistry{at}sdstate.edu.

We conducted 2 studies to determine the effect of vitamin D-fortified cheese on vitamin D status and the bioavailability of vitamin D in cheese. The first study was designed to determine the effect of 2 mo of daily consumption of vitamin D₃-fortified (600 IU/d) process cheese on serum 25-hydroxyvitamin D (25-OHD), parathyroid hormone (PTH), and osteocalcin (OC) concentrations among 100 older (60 yr) men and women. Participants were randomized to receive vitamin D-fortified cheese, nonfortified cheese, or no cheese. Serum levels of 25-OHD, PTH, and OC were measured at the beginning and end of the study. There were no differences in 25-OHD, PTH, or OC after 2 mo of fortified cheese intake. The vitamin D-fortified cheese group had a greater decrease in 25-OHD than other groups, due to higher baseline 25-OHD. A second study was conducted to determine whether the bioavailability of vitamin D₂ in cheese (delivering 5880 IU of vitamin D₂/56.7-g serving) and water (delivering 32,750 IU/250 mL) is similar and whether absorption differs between younger and older adults. The second study was a crossover trial involving 2 groups of 4 participants each (younger and older group) that received single acute feedings of either vitamin D₂-fortified cheese or water. Serial blood measurements were taken over 24 h following the acute feeding. Peak serum vitamin D and area under the curve were similar between younger (23 to 50 yr) and older (72 to 84 yr) adults, and vitamin D₂ was absorbed more efficiently from cheese than from water. These studies demonstrated that vitamin D in fortified process cheese is bioavailable, and that young and older adults have similar absorption. Among older individuals, consuming 600 IU of vitamin D₃ daily from cheese for 2 mo was insufficient to increase serum 25-OHD during limited sunlight exposure.

Key Words: process cheese • vitamin D • elderly • bioavailability

Abbreviation key: AI = adequate intake, 25-OHD = 25-hydroxyvitamin D, OC = osteocalcin, PTH = parathyroid hormone.

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