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Invited Review: Bovine Milk Fat Globule Membrane as a Potential Nutraceutical

BioVita Technologies, Bat Yam, Israel

E-mail: vspits20{at}hotmail.com.

For the last 15 yr, a great deal of knowledge has been accumulated on health beneficial factors, protein and nonprotein, of bovine milk fat globule membrane (MFGM). Among the health-beneficial components of the MFGM are cholesterolemia-lowering factor, inhibitors of cancer cell growth, vitamin binders, inhibitor of Helicobacter pylori, inhibitor of beta-glucuronidase of the intestinal Escherichia coli, xanthine oxidase as a bactericidal agent, butyrophilin as a possible suppressor of multiple sclerosis, and phospholipids as agents against colon cancer, gastrointestinal pathogens, Alzheimer’s disease, depression, and stress. All of the above compel us to consider bovine MFGM as a potential nutraceutical.

Key Words: bovine milk fat globule membrane • milk anticancer protein • phospholipid • cholesterolemia

Abbreviation key: BRCT = C-terminal domain of BRCA1 protein, BTN = butyrophilin, CHD = coronary heart disease, EAE = experimental autoimmune encephalomyelitis, FABP = fatty acid binding protein, MFGM = milk fat globule membrane, MOG = myelin oligodendrocyte glycoproteins.

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