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J. Dairy Sci. 88:1364-1369
© American Dairy Science Association, 2005.

Short Communication: Serum and Tissue Concentrations of Vitamin D Metabolites in Beef Heifers After Buccal Dosing of 25-Hydroxyvitamin D3

J. D. Rivera1, S. E. Bachman2, M. E. Hubbert2, M. E. Branine3, R. L. Horst4, S. N. Williams5 and M. L. Galyean1

1 Department of Animal and Food Sciences, Box 42141, Texas Tech University, Lubbock 79409-2141
2 Ganado Research, LLC, Amarillo, TX 79109
3 Cactus Research, Ltd., Cactus, TX 79013
4 USDA-ARS National Animal Disease Center, Ames, IA 50010-0070
5 DSM Nutritional Products, Inc., Parsippany, NJ 07054-1298

Corresponding author: M. L. Galyean; e-mail: michael.galyean{at}ttu.edu.

Sixteen crossbred (British x Continental; average un-shrunk body weight = 507.9 kg; SD = 45.6 kg) beef heifers fed a steam-flaked corn-based finishing diet with melengestrol acetate (0.4 mg/heifer daily) included to suppress estrus were used in a completely random design to evaluate the efficacy of buccal administration of 0, 10, 100, or 1000 mg of 25-hydroxyvitamin D3, (25-OH D3). Serum Ca, P, Mg, 25-OH D3, 1,25-dihydroxyvitamin D [1,25-(OH)2 D3], albumin, and protein were measured 24 h before dosing (–24 h), at dosing (0 h), and 6 and 24 h after dosing, after which the cattle were slaughtered at a commercial facility. Samples of kidneys, liver, longissimus lumborum, and triceps brachii were collected and evaluated for concentrations of 1,25-(OH)2 D3. With –24 and 0 h as baseline covariates, a significant time x treatment interaction was observed for serum 25-OH D3 and Ca concentrations, but not for serum 1,25-(OH)2 D3. Supplemental 25-OH D3 doses of 100 and 1000 mg significantly increased serum 25-OH D3 at 24 h after dosing, 1,25-(OH)2 D3 at 6 and 24 h after dosing, and serum Ca at 24 h after dosing. Similarly, buccal dosing of 1000 mg of supplemental 25-OH D3 significantly increased (approximately 2- to 3-fold) concentrations of 1,25-(OH)2 D3 in the kidney, liver, and longissimus lumborum relative to the other 3 treatments but not in triceps brachii. Serum albumin, protein, P, and Mg were not affected by treatment. Based on these results, buccal administration of 100 and 1000 mg 25-OH D3 increased vitamin D3 metabolites in serum and tissues, and it should be an effective method of delivering the vitamin.

Key Words: beef cattle • calcium • vitamin D

Abbreviation key: 25-OH D3 = 25-hydroxyvitamin D3, 1,25-(OH)2 D3 = 1,25-dihydroxy vitamin D3, PG = propylene glycol




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M. S. Taylor, K. F. Knowlton, M. L. McGilliard, W. M. Seymour, and J. H. Herbein
Blood Mineral, Hormone, and Osteocalcin Responses of Multiparous Jersey Cows to an Oral Dose of 25-Hydroxyvitamin D3 or Vitamin D3 Before Parturition
J Dairy Sci, June 1, 2008; 91(6): 2408 - 2416.
[Abstract] [Full Text] [PDF]


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