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1 Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway
2 Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway
Corresponding author: H. G. Olsen; e-mail: hanne-gro.olsen{at}iha.nlh.no.
Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat percentage and protein percentage. This effect seemed to be caused by a QTL allele embedded in one specific marker haplotype that caused a reduction in fat and protein yields and a concomitant increase of milk yield, thus resulting in a marked reduction of fat and protein percentages.
Key Words: cattle • fine mapping • linkage disequilibrium • milk
Abbreviation key: BTA = bovine (Bos taurus) chromosome, IBD = identical by descent, LA = linkage analysis, LD = linkage disequilibrium, logL = logarithm of the likelihood
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