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1 Department of Population Medicine, University of Guelph, Ontario, Canada N1G 2W1
2 Department of Large Animal Clinical Science, Michigan State University, East Lansing 48824
3 Roche Vitamins Inc., Parsippany, NJ 07054-1298
Corresponding author: S. LeBlanc; e-mail: sleblanc{at}ovc.uoguelph.ca.
Peripartum decreases in serum concentrations of vitamins A and E may contribute to impaired immune function in dairy cows. The objectives of this study were to describe peripartum serum concentrations of 
-tocopherol, ß-carotene, and retinol and their associations with disease risk. On 20 farms over 1 yr, blood samples were collected weekly from 1057 cows from 1 wk before expected calving until 1 wk postpartum. Serum concentrations of -tocopherol, ß-carotene, and retinol, as well as several biochemical variables were measured. Their associations with the risk of retained placenta or clinical mastitis were modeled separately with logistic regression, and the factors associated with the concentration of each vitamin were modelled with mixed linear regression. Differences in vitamin concentrations between 2 batches of sera analyzed 6 mo apart required stratification of statistical analyses. Accounting for the effects of parity, season, and twins, an increase in -tocopherol of 1 µg/mL in the last week prepartum reduced the risk of retained placenta by 20%, whereas serum nonesterified fatty acid concentration 
0.5 mEq/L tended to increase risk of retained placenta by 80%. In the last week prepartum, a 100 ng/mL increase in serum retinol was associated with a 60% decrease in the risk of early lactation clinical mastitis. There were significant positive associations of peripartum serum concentrations among each of -tocopherol, ß-carotene, and retinol.
Key Words: vitamin A • vitamin E • retained placenta • mastitis
Abbreviation key: RP = retained placenta
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