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1 Institute of Animal Sciences, ARO, The Volcani Center, Bet Dagan 50250, Israel
2 Israel Cattle Breeders Association, Caesaria Industrial Park, Caesaria 38900, Israel
Corresponding author: J. I. Weller; e-mail: weller{at}agri.huji.ac.il.
Eleven Israeli Holstein families including 5221 cows were analyzed by a daughter design for eight economic traits: milk, fat and protein production, fat and protein percentage, somatic cell score (SCS), herd-life, and female fertility. The cows were genotyped for 73 microsatellites with maximum spacing between markers of 53 cM. There were 86,304 informative genotypes. Preliminary analysis was by ANOVA of each trait, with the marker effect nested within sire. Significance was determined by controlling the false discovery rate at 0.4, after excluding markers with genome-wide significance for at least a single trait, and traits without any significant effects at this level. Thus, four markers on chromosomes 6 and 14 and female fertility were excluded. There remained 40 significant marker-trait combinations, and it is expected that 24 of these are true effects. To perform interval mapping for the families with significant contrasts, 21 additional markers were genotyped on chromosomes 2, 7, and 27. The bootstrap confidence intervals for gene effect did not include zero for protein percent on chromosome 2 and fat yield, protein yield, and SCS on chromosome 7. Quantitative trait locus heterozygosity was 33%, which is consistent with the hypothesis that only two alleles are segregating with unequal allele frequency.
Key Words: cattle microsatellite • genome scan • quantitative trait locus • daughter design
Abbreviation key: BTA = Bos taurus autosome, CI95 = 95% confidence intervals, FDR = false discovery rate
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