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1 Department of Animal Science and
2 Department of Population Health and Reproduction, University of California, Davis 95616
Corresponding author: J. D Murray; e-mail: jdmurray{at}ucdavis.
Stearoyl-CoA desaturase enzyme converts specific medium- and long-chain saturated fatty acids to their monounsaturated form. Transgenic goats expressing a bovine ß-lactoglobulin promoter-rat stearoyl-CoA desaturase cDNA construct in mammary gland epithelial cells were produced by pronuclear microinjection. The fatty acid composition of milk from 4 female transgenic founders was analyzed on d 7, 14, and 30 of their first lactation. In 2 animals, the expression of the transgene changed the overall fatty acid composition of the resulting milk fat to a less saturated and more monounsaturated fatty acid profile at d 7 of lactation; however, this effect diminished by d 30. In addition, one animal had an increased proportion of the rumen-derived monounsaturated fatty acid C18:1 trans11 converted by stearoyl-CoA desaturase to the conjugated linoleic acid isomer C18:2 cis9 trans11. Milk that has higher proportions of monounsaturated fatty acids and conjugated linoleic acid may have benefits for human cardiovascular health.
Key Words: stearoyl-CoA desaturase transgenic milk fat conjugated linoleic acid
Abbreviation key: Blg = ß-lactoglobulin, CLA = conjugated linoleic acid, FA = fatty acid, MUFA = monounsaturated fatty acid, PUFA = polyunsaturated fatty acid, SCD = stearoyl-CoA desaturase, SFA = saturated fatty acid.
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