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Characterization of a Colostrum Replacer and a Colostrum Supplement Containing IgG Concentrate and Growth Factors

¹ APC, Inc., Ames, IA 50010
² Department of Dairy Science, Iowa State University, Ames 50011

Corresponding author: C. Hammer; carolyn.hammer{at}amerprotcorp.com.

The objective of this study was to characterize absorption of colostrum replacer (CR) or supplement (CS) containing fractions of bovine plasma. Immunoglobulin concentrate (IGC) was prepared from bovine blood to a final purity of approximately 90% IgG. Blood was also processed to produce a fraction containing elevated concentrations of IGF-I and TGF-ß (GF). Both IGC and GF were spray-dried and blended with other ingredients to produce CR (30% IgG) or CS (15% IgG) containing 0 or 5% GF. Holstein bull calves were assigned to one of five treatments: 1) Pooled colostrum (MC) - 1.9 L of pooled colostrum at 1 and 8 h of age to provide over 150 g of IgG; 2) Low supplement (LC) - 1.9 L of CS at 1 and 8 h of age to provide 150 g of IgG; 3) Low supplement + GF (LG) - 1.9 L of a CS with GF at 1 and 8 h of age to provide 150 g of IgG; 4) High supplement (HC) - 1.9 L of CR at 1 h of age to provide 150 g of IgG and 1.9 L of a commercial milk replacer (MR) at 8 h of age; and 5) High supplement + GF (HG) - 1.9 L of a CR with GF at 1 h of age to provide 150 g of IgG and 1.9 L of MR at 8 h of age. Apparent efficiency of IgG absorption was higher for calves fed HC and HG compared with those fed LC and LG and was lower for calves fed LG and HG compared with those fed LC and HC. IgG concentrations at 24 h were highest in calves fed MC compared with other calves and were higher in calves fed HC and HG compared to LC and LG. Calves fed LG and HG had lower IgG concentrations at 24 h of age compared with those fed LC and HC. These results indicate that 150 g of IgG provided in one dose soon after birth is superior to 150 g of IgG fed in two doses 7 h apart. Also, addition of a plasma fraction containing elevated concentrations of IGF-I and TGF-ß decreased IgG absorption in the neonatal calf.

Key Words: colostrum replacer • immunoglobulin G • calf

Abbreviation key: AEA = apparent efficiency of IgG absorption, CR = colostrum replacer, CS = colostrum supplement, FPT = failure of passive transfer, GF = serum fraction with elevated IGF-I and TGF-ß, HC = high supplement, HG = high supplement plus GF, IGC = immunoglobulin concentrate, IGF-I = insulin like growth factor-I, LC = low supplement, LG - low supplement plus GF, MC = pooled colostrum, MR = milk replacer, TGF-ß = transforming growth factor ß

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				J. M. Campbell, L. E. Russell, J. D. Crenshaw, E. M. Weaver, S. Godden, J. D. Quigley, J. Coverdale, and H. Tyler Impact of Irradiation and Immunoglobulin G Concentration on Absorption of Protein and Immunoglobulin G in Calves Fed Colostrum Replacer J Dairy Sci, December 1, 2007; 90(12): 5726 - 5731. [Abstract] [Full Text] [PDF]