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Insulin-like Growth Factor-I and Its Binding Proteins in Colostrum Compared to Measures in Serum of Holstein Neonates¹

A. L. Sparks^*, J. G. Kirkpatrick, C. S. Chamberlain^*, D. Waldner^* and L. J. Spicer^*

^* Department of Animal Science and
Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK 74078

Corresponding author:
L. J. Spicer; e-mail:
igf1Leo{at}okstate.edu.

Colostral insulin-like growth factor-I (IGF-I) may be beneficial in the development of gastrointestinal tracts of bovine neonates. Thus, the purpose of this study was to examine relationships among concentrations of IGF-I and IGF-binding proteins (IGFBP) in colostrum used at two initial feedings and serum concentrations of IGF-I, IGFBP, total protein, gamma glutamyltransferase (GGT), and immunoglobulin G at 0 and 48 h after birth in Holstein neonates. Calves (n = 22) were separated from dams immediately after birth. Blood samples were taken before initial feeding and at 48 h after birth. Calves were fed 2 L of colostrum twice and milk replacer thereafter. Linear regression of serum IGF-I at 48 h and colostral IGF-I revealed a significant positive relationship (R² = 0.204). Serum IGFBP-3 at 48 h and colostral IGFBP-3 also had a positive relationship (R² = 0.143). However, linear regression of colostral IGF-I on the difference in serum IGF-I at 48 and 0 h was not significant. Calves were assigned to group 1 (0-h serum IGF-I < 10 ng/ml; n = 11) or group 2 (0-h serum IGF-I 10 ng/ml; n = 11) for further analysis. There were no differences in serum IGF-I or IGFBP-2, -3, -4, and -5 concentrations at 48 h between groups 1 and 2. Correlation coefficients revealed negative relationships of serum IGF-I at 0 h to the difference between serum IGF-I at 48 and 0 h (r = -0.824), as well as birth weight of the calf to the amount of GGT at 48 h (r = -0.604). Females had lower birth weights than males, but sex of calf did not affect serum measures. At 0 h, but not 48 h, total serum protein was correlated to serum GGT concentrations (r = 0.573). From indirect evidence, absorption of colostral IGF-I and IGFBP-3 into systemic circulation may occur, but relative importance compared to endogenous sources is uncertain.

Key Words: IGF-I • IGF binding protein • neonatal calf • colostrum

Abbreviation key: ADU = arbitrary densitometric units, GGT = gamma glutamyltransferase, IGFBP = insulin-like growth factor binding protein(s), IgG = immunoglobulin G

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