| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Treatment in Lactating Cows
* Department of Animal Production, National Agricultural Research Organization, National Agricultural Research Center for Tohoku Region, Iwate-ken 020-0198, Japan
School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori-ken 034-8628, Japan
Department of Science of Biology Function, Tohoku University, Miyagi-ken, 981-0914, Japan
Department of Animal Immunology, National Agricultural Research Organization, National Institute of Animal Health, Ibaraki-ken 305-0856, Japan
Corresponding author:
Shiro Kushibiki; e-mail:
mendoza{at}affrc.go.jp.
This study examined the effects of recombinant bovine tumor necrosis factor-
(rbTNF) administration on metabolic and hormonal responses and lactational performance in dairy cows. Twelve lactating Holstein cows were injected subcutaneously with rbTNF (2.5 µg per kg per d) or saline (3 ml per head per d) at 1200 h daily for 7 d (d 0 – 6) and used in a crossover design. The rbTNF treatment induced increases in plasma haptoglobin, nonesterified fatty acid, cortisol, and growth hormone levels compared with the control levels. The rbTNF-treated cows had lower triiodothyronine and insulin-like growth factor-1 concentrations than control cows. In a somatoliberin challenge on d 6, the somatotropin response to somatoliberin (0.25 µg/kg) was smaller in the rbTNF group than in the control. The rbTNF treatment also produced increases of the nitrite plus nitrate concentration in plasma and milk during the period between d 1 and 7. Milk yield was reduced by rbTNF administration from d 1 to 8. The percentage of milk fat was increased on d 1 – 7 by rbTNF treatment, but milk protein content in the rbTNF group was decreased on d 5 and 7 as compared with that in the control group. These results support the possibility that tumor necrosis factor- is responsible for the changes in hormone secretion, milk production and composition, and inflammatory parameters observed during coliform mastitis.
Key Words: recombinant bovine tumor necrosis factor- • metabolite • hormone • mastitis
Abbreviation key: APR = acute phase response, HP = haptoglobin, IGF-1 = insulin-like growth factor 1, LPS = lipopolysaccharide, NEFA = nonesterified fatty acid, NO = nitric oxide, NOx = nitrite plus nitrate, rbTNF = recombinant bovine tumor necrosis factor-, ST = somatotropin, STRH = somatoliberin, TNF = tumor necrosis factor-, T3 = triiodothyronine
This article has been cited by other articles:
|
|
 |
|
  M. R. Waldron, A. E. Kulick, A. W. Bell, and T. R. Overton Acute Experimental Mastitis Is Not Causal Toward the Development of Energy-Related Metabolic Disorders in Early Postpartum Dairy Cows J Dairy Sci, February 1, 2006; 89(2): 596 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Loor, H. M. Dann, R. E. Everts, R. Oliveira, C. A. Green, N. A. J. Guretzky, S. L. Rodriguez-Zas, H. A. Lewin, and J. K. Drackley Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function Physiol Genomics, October 17, 2005; 23(2): 217 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bobe, J. W. Young, and D. C. Beitz Invited Review: Pathology, Etiology, Prevention, and Treatment of Fatty Liver in Dairy Cows J Dairy Sci, October 1, 2004; 87(10): 3105 - 3124. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
