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J. Dairy Sci. 86:792-798
© American Dairy Science Association, 2003.

Pharmacodynamics of Isoflupredone Acetate in an Endotoxin-Induced Mastitis Model

S. A. Wagner and M. D. Apley

Department of Veterinary Diagnostic and Production Animal Medicine College of Veterinary Medicine Iowa State University, Ames 50011

Corresponding author:
S. A. Wagner; e-mail:
sawagner{at}iastate.edu.

The effect of intravenous administration of the steroidal drug isoflupredone acetate on lactating dairy cows with mastitis induced using gram-negative bacterial endotoxin was investigated. Cows were randomly assigned to one of four treatment groups: untreated controls, isoflupredone acetate only, mastitis only, and mastitis plus isoflupredone acetate. Isoflupredone acetate was given to treated groups at a dose of 20 mg intravenously, once. Mastitic cows receiving treatment were given isoflupredone acetate after the development of clinical signs. When compared with untreated mastitic controls, cows with endotoxin-induced mastitis treated with isoflupredone acetate did not exhibit measurable differences in heart rate, rectal temperature, rumen motility, or changes in mammary gland surface area in the 14 h following the administration of intramammary endotoxin. Healthy cows treated with isoflupredone acetate had a higher heart rate over the 14 h after drug administration than did untreated healthy controls. When compared with untreated mastitic controls, cows treated with isoflupredone acetate did not exhibit statistically significant differences in milk production following endotoxin-induced mastitis.

Key Words: mastitis • steroid • milk production

Abbreviation key: LPS = lipopolysaccharide






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