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Hot Topic: An Association Between a Leptin Single Nucleotide Polymorphism and Milk and Protein Yield

F. C. Buchanan^*, A. G. Van Kessel^*, C. Waldner, D. A. Christensen^*, B. Laarveld^* and S. M. Schmutz^*

^* Department of Animal and Poultry Science and
Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Canada

Corresponding author: F. C. Buchanan; e-mail: Buchanan{at}sask.usask.ca.

Allelic variation (C to T transition that results in an Arg25Cys) in the leptin gene has been associated with increased fat deposition in beef cattle. We report that this same genetic variant is also present in dairy breeds. Body fat reserves play an important role in sustaining high milk production in early lactation, when energy intake is limited. To test for an association between the leptin single nucleotide polymorphism and milk productivity, we genotyped 416 Holstein cows and compared lactation performance data using a mixed model. Animals homozygous for the T allele produced more milk (1.5 kg/d vs. CC animals) and had higher somatic cell count linear scores, without significantly affecting milk fat or protein percent over the entire lactation. The increase in milk yield is most prominent in the first 100 d of lactation (2.44 kg/d), declining to 1.74 kg/d between 101 and 200 d in lactation. The milk yield advantage, observed in cows homozygous for the T allele, could represent a major economic advantage to dairy producers.

Key Words: leptin gene • allelic variation • milk productivity • immune response

Abbreviation key: SNP = single nucleotide polymorphism

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