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* Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, D-18196 Dummerstorf, Germany
Institut für Tierzucht und Tierhaltung, Christian-Albrechts-Universität, D-24098 Kiel, Germany
Institut für Tierzucht und Haustiergenetik der Justus-Liebig-Universität, D-35390 Gießen, Germany
Institut für Tierzucht der Ludwig-Maximilians-Universität, D-80539 München, Germany
|| Institut für Veterinärmedizin der Georg-August-Universität, D-37073 Göttingen, Germany
# Vereinigte Informationssysteme Tierhaltung w.V., D-27283 Verden, Germany
** Tierzuchtforschung e.V., D-85586 Grub, Germany
Bayerische Landesanstalt für Tierzucht, D-85586 Grub, Germany
Institut für die Fortpflanzung landwirtschaftlicher Nutztiere, D-16321 Schönow, Germany
Corresponding author:
Christa Kühn; e-mail:
kuehn{at}fbn-dummerstorf.de.
A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breeding values for maternal and direct effects on dystocia (DYSm, DYSd) and stillbirth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.
Key Words: quantitative trait loci • functional traits • Holstein cattle
Abbreviation key: ADR = German Cattle Breeders Federation, BTA = Bos taurus chromosome, CVM = complex vertebral malformation, DYD = daughter yield deviation, DYSd = dystocia (direct effect), DYSm = dystocia (maternal effect), FHL = functional herd life, MAS = marker assisted selection, NR90m = nonreturn rate of 90 d (maternal effect), NR90p = nonreturn rate of 90 d (paternal effect), REBV = relative estimated breeding value, SSCP = single strand conformation polymorphism, STId = stillbirth (direct effect), STIm = stillbirth (maternal effect), X/Yps = pseudoautosomal region of the sex chromosomes
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