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* University of Guelph, Guelph, Ontario N1G 2W1, Canada
Quality Milk Promotion Services, Cornell Univesity, Ithaca New York 14850-1263 USA
University of Montreal, St. Hyacinthe, Quebec J2S 7C6 Canada
University of Prince Edward Island, Charlottetown, P.E.I. C1A 4P3 Canada
|| Tavistock Veterinarians, 25 Hope St. East Tavistock, Ontario, N0B 2R0
# Provel, Division of Eli Lilly Canada Inc., Research Park Centre, Guelph, Ontario N1G 4T2 Canada
Corresponding author:
R. T. Dingwell; e-mail:
rdingwell{at}vet.k-state.edu.
The objective of this study was to evaluate the efficacy of intramammary tilmicosin, administered at drying-off, for eliminating Staphylococcus aureus infection, and to identify risk factors for S. aureus cure during the dry period. A total of 219 naturally infected cows, representing 308 quarters, were randomized to receive either one of two treatments at drying-off. Cows received either an intramammary infusion of 500 mg of benzathine cloxacillin, or a sterile solution containing 1500 mg of tilmicosin. All cows had quarter milk samples taken aseptically three times before dry-off, and at wk 1, 2, and 4 of the subsequent lactation. Overall, 62% of cows and 67.5% of quarters infected with S. aureus cured during the dry period. The cure following administraton of tilmicosin was 67.3 and 72.5% for cows and quarters, respectively. By comparison, the cure achieved with cloxacillin was 56.9 and 62.9% of cows and quarters. Cows receiving tilmicosin were 2.1 times more likely to cure. The cure rate for cows decreased as the linear score on the last DHI test increased, and as the amount of S. aureus being shed increased. Quarters that cultured positive multiple times before drying-off were less likely to cure. Staphylococcus aureus infections located in front quarters of the udder were 2 times more likely to cure than those in hind quarters. Results of this study demonstrate that intramammary tilmicosin at drying-off is efficacious in curing existing S. aureus during the dry period. Risk factors associated with the cure of S. aureus were identified.
Key Words: Staphylococcus aureus • dry cow therapy • tilmicosin
Abbreviation key: CNS = coagulase-negative staphylococci, CP5 = capsular polysaccharide 5, DCT = dry cow antibiotic therapy, LS = linear score, OR = odds ratio
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