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Journal of Dairy Science Vol. 85 No. 2 406-412
© 2002 by American Dairy Science Association ®
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Paratuberculosis in Dairy Cattle: Variation of the Antibody Response in Offspring Attributable to the Dam

S. S. Nielsen 1, Y. T. Gröhn 2, R. L. Quaas 3, and J. F. Agger 1

1 Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Grønnegårdsvej 8, DK-1870 Frederiksberg C, Denmark
2 Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
3 Department of Animal Science, Cornell University, Ithaca, New York 14853

The objective of this study was to examine transmission of paratuberculosis in dairy cattle attributable to the dam. Milk samples were collected from 8131 cows in 110 Danish dairy herds. The level of antibodies to Mycobacterium avium subspecies paratuberculosis was determined by use of an ELISA. Information on dam and sire was obtained from the Danish Cattle database. The following two data sets were analyzed: Data set A contained all cows le400 days in milk (n = 7410); data set B contained 1056 dam-daughter pairs present simultaneously in herds at the day of sampling. Cows > 400 days in milk were excluded. Linear mixed models were used to obtain variance components for the effect of sire in data set A and the effect of sire and dam-daughter pairs in data set B. Models for both data sets A and B included information previously shown to confound antibody level and information of the relative prevalence of paratuberculosis in the herd. In data set A, the effect explained by sire was 1.9%, whereas it was 6.3% in data set B. The effect from dam-daughter pairs was 7.7%. Those effects were all significant. It was concluded that the parental contribution was significant, and both heritability of susceptibility and vertical transmission should be considered in any control programs on paratuberculosis in dairy cattle.

Key Words: Paratuberculosis • transmission • antibody variation

Submitted on May 9, 2001
Accepted on September 26, 2001




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