| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 United States Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030
2 United States Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030
3 The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030 and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030
Insulin-like growth factor I (IGF-I) is known to regulate mammary gland development. This regulation occurs through effects on both cell cycle progression and apoptosis. Our laboratory has studied the IGF-I-dependent regulation of these processes by using transgenic and knockout mouse models that exhibit alterations in the IGF-I axis. Our studies of transgenic mice that overexpress IGF-I during pregnancy and lactation have demonstrated that this growth factor slows the apoptotic loss of mammary epithelial cells during the declining phase of lactation but has minimal effects during early lactation on milk composition or lactational capacity. In contrast, our analysis of early developmental processes in mammary tissue from mice carrying a targeted mutation in the IGF-I receptor gene suggests that IGF-dependent stimulation of cell cycle progression is more important to early mammary gland development than potential anti-apoptotic effects. With both models, the effects of perturbing the IGF-I axis are dependent on the physiological state of the animal. The diminished ductal development that occurs in response to loss of the IGF-I receptor is dramatically restored during pregnancy, whereas the ability of overexpressed IGF-I to protect mammary cells from apoptosis does not occur if the mammary gland is induced to undergo forced involution. Data from our laboratory on the expression of IGF-signaling molecules in the mammary gland suggest that this effect of physiological context may be related to the expression of members of the insulin receptor substrate family.
Key Words: IGF-I • mammary • transgenic • knockout
Submitted on August 2, 2001
Accepted on October 9, 2001
This article has been cited by other articles:
|
|
 |
|
  S. G. Miranda, Y. J. Wang, N. G. Purdie, V. R. Osborne, B. L. Coomber, and J. P. Cant Selenomethionine stimulates expression of glutathione peroxidase 1 and 3 and growth of bovine mammary epithelial cells in primary culture J Dairy Sci, June 1, 2009; 92(6): 2670 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Kleinberg, T. L. Wood, P. A. Furth, and A. V. Lee Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions Endocr. Rev., February 1, 2009; 30(1): 51 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. P. Silva, B. E. Etchebarne, M. S. Weber Nielsen, J. S. Liesman, M. Kiupel, and M. J. VandeHaar Intramammary Infusion of Leptin Decreases Proliferation of Mammary Epithelial Cells in Prepubertal Heifers J Dairy Sci, August 1, 2008; 91(8): 3034 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Carver and L. A. Schuler Prolactin Does Not Require Insulin-Like Growth Factor Intermediates but Synergizes with Insulin-Like Growth Factor I in Human Breast Cancer Cells Mol. Cancer Res., April 1, 2008; 6(4): 634 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Annen, A. C. Fitzgerald, P. C. Gentry, M. A. McGuire, A. V. Capuco, L. H. Baumgard, and R. J. Collier Effect of Continuous Milking and Bovine Somatotropin Supplementation on Mammary Epithelial Cell Turnover J Dairy Sci, January 1, 2007; 90(1): 165 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Akers Major advances associated with hormone and growth factor regulation of mammary growth and lactation in dairy cows. J Dairy Sci, April 1, 2006; 89(4): 1222 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Hadsell, D. T. Torres, N. A. Lawrence, J. George, A. F. Parlow, A. V. Lee, and M. L. Fiorotto Overexpression of Des(1-3) Insulin-Like Growth Factor 1 in the Mammary Glands of Transgenic Mice Delays the Loss of Milk Production with Prolonged Lactation Biol Reprod, December 1, 2005; 73(6): 1116 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Donovan, J. L. Hartke, M. H. Monaco, and M. B. Wheeler Insulin-like Growth Factor-I and Piglet Intestinal Development J Dairy Sci, July 1, 2004; 87(13_suppl): E47 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Naylor, E. Ginsburg, T. P. Iismaa, B. K. Vonderhaar, D. Wynick, and C. J. Ormandy The Neuropeptide Galanin Augments Lobuloalveolar Development J. Biol. Chem., August 1, 2003; 278(31): 29145 - 29152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Capuco, S. E. Ellis, S. A. Hale, E. Long, R. A. Erdman, X. Zhao, and M. J. Paape Lactation persistency: Insights from mammary cell proliferation studies J Anim Sci, March 1, 2003; 81(suppl_3): 18 - 31. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
