JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 85 No. 1 60-67
© 2002 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chaiyotwittayakun, A.
Right arrow Articles by Harmon, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaiyotwittayakun, A.
Right arrow Articles by Harmon, R. J.

The Effect of Ascorbic Acid and L-Histidine Therapy on Acute Mammary Inflammation in Dairy Cattle

A. Chaiyotwittayakun 1, R. J. Erskine 2, P. C. Bartlett 2, T. H. Herdt 2, P. M. Sears 2, and R. J. Harmon 3

1 Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824 and Department of Veterinary Medicine Khon Kaen University, Thailand 40002
2 Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824
3 Department of Animal Sciences, University of Kentucky, Lexington 40546

Ascorbic acid and L-histidine were investigated as antioxidant therapies for acute mammary inflammation. Mastitis was induced in eight nonpregnant Holstein cows by intramammary infusion of endotoxin. Treatments were administered in a 4 x 4 Latin square crossover design with 1-wk periods between challenges with endotoxin. Four individual treatments, control, ascorbic acid only, L-histidine only, and ascorbic acid plus L-histidine, were applied. Two doses of 25 g of ascorbic acid administered intravenously at 3- and 5-h postendotoxin challenge increased milk production recovery (9% higher, P < 0.02) and tended to reduce the extent of rumen stasis. Two doses of 25 g of L-histidine similarly administered decreased plasma antioxidant activities 5.5% (P < 0.05). However, ascorbic acid and L-histidine had no effects on rectal temperature, heart rate, respiratory rate, and dry matter intake. The data suggested that ascorbic acid provided some potential benefit for recovery from acute mammary inflammation in dairy cattle.

Key Words: ascorbic acid • inflammation • L-histidine • mastitis

Submitted on August 8, 2000
Accepted on August 28, 2001




This article has been cited by other articles:


Home page
 J ANIM SCIHome page
L. Padilla, T. Matsui, S. Ikeda, M. Kitagawa, and H. Yano
The effect of vitamin C supplementation on plasma concentration and urinary excretion of vitamin C in cattle
J Anim Sci, December 1, 2007; 85(12): 3367 - 3370.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
W. P. Weiss and J. S. Hogan
Effects of Dietary Vitamin C on Neutrophil Function and Responses to Intramammary Infusion of Lipopolysaccharide in Periparturient Dairy Cows
J Dairy Sci, February 1, 2007; 90(2): 731 - 739.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
W. P. Weiss and J. S. Hogan
Effect of Selenium Source on Selenium Status, Neutrophil Function, and Response to Intramammary Endotoxin Challenge of Dairy Cows
J Dairy Sci, December 1, 2005; 88(12): 4366 - 4374.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
W. P. Weiss, J. S. Hogan, and K. L. Smith
Changes in Vitamin C Concentrations in Plasma and Milk from Dairy Cows After an Intramammary Infusion of Escherichia coli
J Dairy Sci, January 1, 2004; 87(1): 32 - 37.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Dairy Science Association ®.