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SCoA Reductase Inhibitors
1 Wadsworth Center for Laboratories and Research, New York State Department of Health, Empire State Plaza, Albany, New York 12201-0509
Two hydroxymethylglutaryl
SCoA (HMG-CoA) reductase inhibitors, mevastatin and lovastatin, inhibited the in vitro growth and production of CH4 of strains of Methanobrevibacter isolated from the rumen. Mevastatin or lovastatin did not inhibit growth of species of rumen bacteria that are essential for fermenting cellulose, starch and other plant polysaccharides to acetate, propionate, and butyrate. Approximately 4 nmol of lovastatin per milliliter resulted in 50% growth inhibition of Methanobrevibacter strain ZA10 and concentrations 
10 nmol per milliliter completely inhibited growth and CH4 formation. Results of in vitro growth studies suggest that supplementation of ruminant feeds with HMG-CoA inhibitors could decrease ruminant methane production and increase the efficiency of feed utilization by domestic ruminants.
Key Words: methanogens • rumen methane inhibitor • hydroxymethylglutarylCoA inhibitors • lovastatin
Submitted on September 22, 2000
Accepted on January 29, 2001
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