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1 Institute of Animal Nutrition, University of Zurich, 8057 Zurich, Switzerland
2 Clinic for Food Animals and Horses, University of Berne, 3012 Bern, Switzerland
3 Department of Clinical Chemistry, University of Oulu, 90220 Oulu, Finland
4 Endocrine Unit, University Hospital, 4031 Basel, Switzerland
Substantial changes occur in skeletal metabolism during lactation. These dynamic changes are monitored with biochemical bone markers. The goal of the present study was to follow these changes in lactating cows and to investigate whether cows with a higher milk yield have a higher mobilization rate of calcium from bone. Hydroxyproline, deoxypyridinoline, pyridinoline, and the carboxyterminal telopeptide of type I collagen (ICTP) were chosen as markers for bone resorption, whereas osteocalcin was used as a bone formation marker.
Urine and blood samples were collected from cows with a mean standard milk yield of 4900 and 6500 kg, respectively, 14 d before, and 14 d, 1 mo, 1.5 mo, and monthly after parturition.
Urinary hydroxyproline, deoxypyridinoline, and pyridinoline concentrations increased with time, but no differences between the two groups were evident. Concentrations of 1,25-dihydroxy vitamin D and ICTP of the two groups showed an increase 14 d after parturition. Furthermore, using multivariate regression models with age and milk yield as covariates, ICTP concentrations were higher in the group with a higher milk yield. In contrast, osteocalcin concentrations decreased 14 d after parturition and returned to prepartum values 1 mo after parturition.
Key Words: bone markers • lactation • dairy cows • parturition
Submitted on November 8, 1999
Accepted on March 10, 2000
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