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Journal of Dairy Science Vol. 83 No. 3 401-403
© 2000 by American Dairy Science Association ®
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Effect of Lactobacillus reuteri on the Prevention of Hypercholesterolemia in Mice

M. P. Taranto 1, M. Medici 1, G. Perdigon 1, A. P. Ruiz Holgado 1, and G. F. Valdez 2

1 Centro de Referencia para Lactobacilos (CERELA), CONICET, Chacabuco 145, 4000, San Miguel de Tucumán, Argentina
2 Centro de Referencia para Lactobacilos (CERELA), CONICET, Chacabuco 145, 4000, San Miguel de Tucumán, Argentina and Cátedra de Microbiología Superior, Facultad Bioquímica, Química, and Farmacia, Universidad Nacional de Tucumán, 4000, San Miguel de Tucumán, Argentina

Administration of Lactobacillus reuteri CRL 1098 (104 cells/d) to mice for 7 d before inducing hypercholesterolemia (by feeding mice with a fat-enriched diet for the subsequent 7 d) was evaluated. At this low dose, L. reuteri was effective in preventing hypercholesterolemia in mice, producing a 17% increase in the ratio of high-density lipoprotein to low-density lipoprotein. Total cholesterol and triglycerides decreased by 22 and 33%, respectively, in the group that was not fed the lactobacilli. The hypocholesterolemic effect produced by L. reuteri CRL 1098 might be considered as indirect evidence of the permanency of the lactobacilli in the gut.

Key Words: Lactobacillus reuteri • hypocholesterolemia • probiotic

Submitted on April 28, 1999
Accepted on November 15, 1999




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