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Journal of Dairy Science Vol. 83 No. 2 203-247
© 2000 by American Dairy Science Association ®
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A Review and Proposed Nomenclature for Major Proteins of the Milk-Fat Globule Membrane

Ian H. Mather 1

1 Department of Animal and Avian Sciences, University of Maryland, College Park 20742

The characteristics and possible functions of the most abundant proteins associated with the bovine milk-fat globule membrane are reviewed. Under the auspices of the Milk Protein Nomenclature Committee of the ADSA, a revised nomenclature for the major membrane proteins is proposed and discussed in relation to earlier schemes. We recommend that proteins be assigned specific names as they are identified by molecular cloning and sequencing techniques. The practice of identifying proteins according to their Mr, electrophoretic mobility, or staining characteristics should be discontinued, except for uncharacterized proteins. The properties and amino acid sequences of the following proteins are discussed in detail: MUC1, xanthine dehydrogenase/oxidase, CD36, butyrophilin, adipophilin, periodic acid Schiff 6/7 (PAS 6/7), and fatty acid binding protein. In addition, a compilation of less abundant proteins associated with the bovine milk-fat globule membrane is presented.

Key Words: milk-fat globule membrane proteins • nomenclature • review

Submitted on July 22, 1999
Accepted on October 18, 1999




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