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Journal of Dairy Science Vol. 83 No. 12 2810-2812
© 2000 by American Dairy Science Association ®
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Short Communication: Effects of Monensin on 3-Methylhistidine Excretion in Transition Dairy Cows

J. C. Plaizier 1, J. P. Walton 1, A. Martin 1, T. Duffield 2, R. Bagg 3, P. Dick 3, and B. W. McBride 1

1 Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada N1G 2W1
2 Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada N1G 2W1 and Provel, Division Eli Lilly Canada Inc., Research Park Centre, Guelph, ON, Canada N1G 4T2
3 Provel, Division Eli Lilly Canada Inc., Research Park Centre, Guelph, ON, Canada N1G 4T2

Urinary 3 methyl-histidine excretion was measured in high yielding dairy cows between 10 and 3 d precalving and between 3 and 9 d postcalving. Cows received a sodium monensin controlled-release capsule or a placebo 3 wk before calving. Monensin did not affect urinary 3 methyl-histidine. Average urinary 3 methyl-histidine excretion was significantly higher postcalving (4.11 mmol d–1) than precalving (2.48 mmol d–1). This increase is assumed to be predominantly due to the negative nitrogen balance in the postcalving period caused by insufficient nutrient intake to meet nutrient requirements, which necessitates catabolism of mainly myofibrillar protein.

Key Words: 3 methyl-histidine • transition • myofibrillar protein • monensin

Submitted on March 27, 2000
Accepted on July 18, 2000




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G. E. Chibisa, G. N. Gozho, A. G. Van Kessel, A. A. Olkowski, and T. Mutsvangwa
Effects of Peripartum Propylene Glycol Supplementation on Nitrogen Metabolism, Body Composition, and Gene Expression for the Major Protein Degradation Pathways in Skeletal Muscle in Dairy Cows
J Dairy Sci, September 1, 2008; 91(9): 3512 - 3527.
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