JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 83 No. 10 2282-2284
© 2000 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kazmer, G. W.
Right arrow Articles by Strausbaught, L. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kazmer, G. W.
Right arrow Articles by Strausbaught, L. D.

Short Communication: Growth Hormone Response to Somatostatin-28 and Growth Hormone-Releasing Factor in Dairy Heifers

G. W. Kazmer 1, S. A. Zinn 1, and L. D. Strausbaught 1

1 Department of Animal Science, Department of Molecular and Cell Biology, University of Connecticut, Storrs 06259

In an attempt to investigate the role of somatostatin-28 (SRIF-28) in modulating growth hormone (GH)-releasing factor (GRF)-induced GH release in dairy cattle, we assigned Holstein heifer calves (n = 12) to receive 0, 10, and 20 µg of SRIF-28/100 kg of BW (0, 10, 20) in conjunction with administration of 3 µg of GRF/100 kg of BW. Administration of 10 or 20 µg of SRIF-28 reduced GRF-induced GH release, because areas under the response curves during 30 min after GRF administration were less when cows received those dosages compared with receiving 0. Some evidence of a dose response was observed because serum GH concentrations increased from 15 to 20 min after GRF administration when animals received 10 µg, but continued to decrease when animals received 20 µg of SRIF-28. We conclude that, in contrast to studies with SRIF-14, pituitary GH release is very sensitive to inhibitory effects of SRIF-28 when used in as little as a fivefold molar excess. Additional experimentation is necessary to determine whether equimolar concentrations of SRIF-28 are effective in altering GRF-induced GH release. Further, these results give rise to speculation that SRIF may be involved in physiological mechanisms mediating well-documented genetic influences on GH concentrations in dairy cattle.

Key Words: somatostatin-28 • growth hormone • growth hormone-releasing factor

Submitted on February 1, 2000
Accepted on April 14, 2000




This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
W. J. Weber, L. H. Baumgard, G. W. Kazmer, S. A. Zinn, L. B. Hansen, H. Chester-Jones, and B. A. Crooker
Growth Hormone Response to Growth Hormone Releasing Hormone in Calves that Differ in Genetic Merit for Milk Yield
J Dairy Sci, May 1, 2005; 88(5): 1723 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M Mondal and B S Prakash
Effects of long-term GH-releasing factor administration on patterns of GH and LH secretion in growing female buffaloes (Bubalus bubalis)
Reproduction, January 1, 2004; 127(1): 45 - 55.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
L. H. Baumgard, W. J. Weber, G. W. Kazmer, S. A. Zinn, L. B. Hansen, H. Chester-Jones, and B. A. Crooker
Effects of Selection for Milk Yield on Growth Hormone Response to Growth Hormone Releasing Factor in Growing Holstein Calves
J Dairy Sci, October 1, 2002; 85(10): 2529 - 2540.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. E. Govoni, X. C. Tian, G. W. Kazmer, M. Taneja, B. P. Enright, A. L. Rivard, X. Yang, and S. A. Zinn
Age-Related Changes of the Somatotropic Axis in Cloned Holstein Calves
Biol Reprod, May 1, 2002; 66(5): 1293 - 1298.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Dairy Science Association ®.