JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 82 No. 9 1904-1909
© 1999 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reinhardt, T. A.
Right arrow Articles by Goff, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reinhardt, T. A.
Right arrow Articles by Goff, J. P.

1,25-Dihydroxyvitamin D3 Enhances Milk Antibody Titers to Escherichia coli J5 Vaccine

T. A. Reinhardt 1, J. R. Stabel 2, and J. P. Goff 1

1 Metabolic Diseases and Immunology, Research Units, Ames, IA 50010
2 Zoonotic Diseases Research Units, Ames, IA 50010

Recent evidence in cattle and mice has suggested that 1,25-dihydroxyvitamin D3 may stimulate T-lymphocyte differentiation pathways responsible for humoral immunity. The use of 1,25-dihydroxyvitamin D3 as an adjuvant for an Escherichia coli J5 vaccine was tested. Ten midlactation cows received J5 vaccine and were revaccinated 6 wk after the first vaccine administration. Five of these cows were given 200 µg of 1,25-dihydroxyvitamin D3, in addition to the primary vaccination, and they received an additional 200 µg of 1,25-dihydroxyvitamin D3 1 wk after the primary vaccination. No 1,25-dihydroxyvitamin D3 was administered with the wk 6 J5 vaccine booster. Milk immunoglobin (Ig)M, IgG, and IgA antibodies to E. coli J5 were significantly increased in cows receiving 1,25-dihydroxyvitamin D3 + E. coli J5 vaccine compared with cows that received only E. coli J5 vaccine. Serum IgG and IgG1 antibodies to E. coli J5 were also significantly enhanced by 1,25-dihydroxyvitamin D3 treatment compared with cows receiving vaccine alone. In contrast, serum IgG2 titers tended to decline in cows receiving 1,25-dihydroxyvitamin D3. Taken together, these data suggest that 1,25-dihydroxyvitamin D3 has potential usefulness in boosting humoral responses to vaccines such as J5 and may further enhance the protective qualities of vaccines.

Key Words: mastitis • vaccine • vitamin D

Submitted on October 20, 1998
Accepted on April 6, 1999




This article has been cited by other articles:


Home page
 J ANIM SCIHome page
J. D. Lippolis
Immunological signaling networks: Integrating the body's immune response
J Anim Sci, April 1, 2008; 86(14_suppl): E53 - E63.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
M. R. Waldron, B. J. Nonnecke, T. Nishida, R. L. Horst, and T. R. Overton
Effect of Lipopolysaccharide Infusion on Serum Macromineral and Vitamin D Concentrations in Dairy Cows
J Dairy Sci, November 1, 2003; 86(11): 3440 - 3446.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
B. J. Nonnecke, K. Kimura, J. P. Goff, and M. E. Kehrli Jr.
Effects of the Mammary Gland on Functional Capacities of Blood Mononuclear Leukocyte Populations from Periparturient Cows
J Dairy Sci, July 1, 2003; 86(7): 2359 - 2368.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Dairy Science Association ®.