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Journal of Dairy Science Vol. 82 No. 7 1459-1464
© 1999 by American Dairy Science Association ®
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Differential Distribution of T Lymphocyte Subpopulations in the Bovine Mammary Gland During Lactation

T. Yamaguchi 1, M. Hiratsuka 2, K. Asai 3, K. Kai 3, and K. Kumagai 3

1 Department of Animal Science, Faculty of Agriculture, Tohoku University, Sendai 981-8555, Japan
2 Miyagi Prefecture Senpoku Meat Sanitation, Inspection Laboratory, Yoneyama-achi, Miyagi 987-0311, Japan
3 T-Cell Research Institute, Sendai 989-3205, Japan

The existence and distribution of T lymphocyte subpopulations in the mammary parenchymal tissue of cows were immunohistochemically detailed during early lactation. CD2+, CD4+, and CD8+ T lymphocytes were localized primarily in the mammary parenchymal tissue. CD8+ T lymphocytes were predominant over CD4+ T lymphocytes and occurred in close contact with the alveolar epithelium and between epithelial cells in the central area of the upper mammary gland. CD4+ T lymphocytes were present in equal numbers in the epithelial and connective tissue area. Occasionally, both CD4+ and CD8+ T lymphocytes formed cell clusters in the interalveolar connective tissue. The ratio of CD4+ T lymphocytes to CD8+ T lymphocytes was less than 1.0 and was lower in the epithelial area than in the connective tissue. The distribution of CD4+ and CD8+ T lymphocytes was similar in the parenchymal tissue of the gland cistern. The observation that there is a preferential presence of CD8+ T lymphocytes in the epithelial area of the bovine mammary gland during early lactation might indicate that these cells participate in the maintenance of the integrity of the epithelium.

Key Words: bovine mammary gland • T lymphocyte • subpopulations • comparative distribution • mammary gland immunity

Submitted on October 20, 1998
Accepted on March 1, 1999




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