| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Human Nutrition Program, Dairy Research and Development Corporation, Melbourne, Australia
Prevention is an important strategy for conquering cancer. Milk fat contains a number of components, such as conjugated linoleic acid, sphingomyelin, butyric acid, ether lipids, ß-carotene, and vitamins A and D that have anticancer potential. Conjugated linoleic acid inhibits the growth of a number of human cancer cell lines and suppresses chemically-induced tumor development at a number of sites in animal models. As little as 0.1% of dietary conjugated linoleic acid inhibits the development of rat mammary tumors, independent of the amount and type of fat in the diet. Sphingomyelin, through its metabolites ceramide and sphingosine, participates in multiple antiproliferative pathways associated with suppression of carcinogenesis. Dietary sphingomyelin inhibits murine colon tumor development. Butyric acid, uniquely present in ruminant milk, is a potent antineoplastic agent and may ameliorate its potency through synergy with other milk fat components. Dietary butyric acid inhibits mammary carcinoma development in rats. In humans, ether lipids, ßcarotene, and vitamins A and D are associated with anticancer effects. Cows have the ability to extract anticarcinogenic components from pasture and feed and transfer them to milk. Use of genetic engineering and other techniques to increase the range and level of anticarcinogens in pasture and supplements may increase the anticancer potential of milk.
Key Words: milk fat • anticarcinogens • conjugated linoleic acid • butyric acid
Submitted on July 27, 1998
Accepted on February 1, 1998
This article has been cited by other articles:
|
|
 |
|
  H. Soyeurt, F. Dehareng, P. Mayeres, C. Bertozzi, and N. Gengler Variation of {Delta}9-Desaturase Activity in Dairy Cattle J Dairy Sci, August 1, 2008; 91(8): 3211 - 3224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Bouwstra, R. M. A. Goselink, P. Dobbelaar, M. Nielen, J. R. Newbold, and T. van Werven The Relationship Between Oxidative Damage and Vitamin E Concentration in Blood, Milk, and Liver Tissue from Vitamin E Supplemented and Nonsupplemented Periparturient Heifers J Dairy Sci, March 1, 2008; 91(3): 977 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Gorocica-Buenfil, F. L. Fluharty, T. Bohn, S. J. Schwartz, and S. C. Loerch Effect of low vitamin A diets with high-moisture or dry corn on marbling and adipose tissue fatty acid composition of beef steers J Anim Sci, December 1, 2007; 85(12): 3355 - 3366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Murphy, G. J. Hooiveld, M. Muller, R. A. Calogero, and K. D. Cashman Conjugated Linoleic Acid Alters Global Gene Expression in Human Intestinal-Like Caco-2 Cells in an Isomer-Specific Manner J. Nutr., November 1, 2007; 137(11): 2359 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. AbuGhazaleh, D. O. Felton, and S. A. Ibrahim Milk Conjugated Linoleic Acid Response to Fish Oil and Sunflower Oil Supplementation to Dairy Cows Managed Under Two Feeding Systems J Dairy Sci, October 1, 2007; 90(10): 4763 - 4769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Soyeurt, A. Gillon, S. Vanderick, P. Mayeres, C. Bertozzi, and N. Gengler Estimation of Heritability and Genetic Correlations for the Major Fatty Acids in Bovine Milk J Dairy Sci, September 1, 2007; 90(9): 4435 - 4442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Gorocica-Buenfil, F. L. Fluharty, C. K. Reynolds, and S. C. Loerch Effect of dietary vitamin A concentration and roasted soybean inclusion on marbling, adipose cellularity, and fatty acid composition of beef J Anim Sci, September 1, 2007; 85(9): 2230 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Torniainen, M. Hedelin, V. Autio, H. Rasinpera, K. A. Balter, A. Klint, R. Bellocco, F. Wiklund, P. Stattin, T. Ikonen, et al. Lactase Persistence, Dietary Intake of Milk, and the Risk for Prostate Cancer in Sweden and Finland Cancer Epidemiol. Biomarkers Prev., May 1, 2007; 16(5): 956 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Alvarez, M. Fresno, P. Mendez, N. Castro, J. R. Fernandez, and M. R. S. Sampelayo Alternatives for Improving Physical, Chemical, and Sensory Characteristics of Goat Cheeses: The Use of Arid-Land Forages in the Diet J Dairy Sci, May 1, 2007; 90(5): 2181 - 2188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ferlay, B. Martin, Ph. Pradel, J. B. Coulon, and Y. Chilliard Influence of grass-based diets on milk Fatty Acid composition and milk lipolytic system in tarentaise and montbeliarde cow breeds. J Dairy Sci, October 1, 2006; 89(10): 4026 - 4041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jinjarak, A. Olabi, R. Jimenez-Flores, and J. H. Walker Sensory, functional, and analytical comparisons of whey butter with other butters. J Dairy Sci, July 1, 2006; 89(7): 2428 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jinjarak, A. Olabi, R. Jimenez-Flores, I. Sodini, and J. H. Walker Sensory evaluation of whey and sweet cream buttermilk. J Dairy Sci, July 1, 2006; 89(7): 2441 - 2450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tricon, G. C Burdge, E. L Jones, J. J Russell, S. El-Khazen, E. Moretti, W. L Hall, A. B Gerry, D. S Leake, R. F Grimble, et al. Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 744 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Shingfield, C. K. Reynolds, G. Hervas, J. M. Griinari, A. S. Grandison, and D. E. Beever Examination of the Persistency of Milk Fatty Acid Composition Responses to Fish Oil and Sunflower Oil in the Diet of Dairy Cows J Dairy Sci, February 1, 2006; 89(2): 714 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Arbones-Mainar, M. A. Navarro, S. Acin, M. A. Guzman, C. Arnal, J. C. Surra, R. Carnicer, H. M. Roche, and J. Osada Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice J. Nutr., February 1, 2006; 136(2): 353 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Jones, K. J. Shingfield, C. Kohen, A. K. Jones, B. Lupoli, A. S. Grandison, D. E. Beever, C. M. Williams, P. C. Calder, and P. Yaqoob Chemical, Physical, and Sensory Properties of Dairy Products Enriched with Conjugated Linoleic Acid J Dairy Sci, August 1, 2005; 88(8): 2923 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Rasinpera, C Forsblom, N S Enattah, P Halonen, K Salo, M Victorzon, J-P Mecklin, H Jarvinen, S Enholm, G Sellick, et al. The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population Gut, May 1, 2005; 54(5): 643 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Herzallah, M. A. Humeid, and K. M. Al-Ismail Effect of Heating and Processing Methods of Milk and Dairy Products on Conjugated Linoleic Acid and Trans Fatty Acid Isomer Content J Dairy Sci, April 1, 2005; 88(4): 1301 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nudda, M. A. McGuire, G. Battacone, and G. Pulina Seasonal Variation in Conjugated Linoleic Acid and Vaccenic Acid in Milk Fat of Sheep and its Transfer to Cheese and Ricotta J Dairy Sci, April 1, 2005; 88(4): 1311 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Lock, B. A. Corl, D. M. Barbano, D. E. Bauman, and C. Ip The Anticarcinogenic Effect of trans-11 18:1 Is Dependent on Its Conversion to cis-9, trans-11 CLA by {Delta}9-Desaturase in Rats J. Nutr., October 1, 2004; 134(10): 2698 - 2704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S McLeod, A. M LeBlanc, M. A Langille, P. L Mitchell, and D. L Currie Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1169S - 1174S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Troegeler-Meynadier, M. C. Nicot, C. Bayourthe, R. Moncoulon, and F. Enjalbert Effects of pH and Concentrations of Linoleic and Linolenic Acids on Extent and Intermediates of Ruminal Biohydrogenation in Vitro J Dairy Sci, December 1, 2003; 86(12): 4054 - 4063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bas, H. Archimede, A. Rouzeau, and D. Sauvant Fatty Acid Composition of Mixed-Rumen Bacteria: Effect of Concentration and Type of Forage J Dairy Sci, September 1, 2003; 86(9): 2940 - 2948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chilliard, A. Ferlay, J. Rouel, and G. Lamberet A Review of Nutritional and Physiological Factors Affecting Goat Milk Lipid Synthesis and Lipolysis J Dairy Sci, May 1, 2003; 86(5): 1751 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Prieto, E. J. DePeters, P. H. Robinson, J. E. P. Santos, J. W. Pareas, and S. J. Taylor Increasing Dietary Levels of Cracked Pima Cottonseed Increase Plasma Gossypol but do not Influence Productive Performance of Lactating Holstein Cows J Dairy Sci, January 1, 2003; 86(1): 254 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Garcia, M. Amstalden, C. D. Morrison, D. H. Keisler, and G. L. Williams Age at puberty, total fat and conjugated linoleic acid content of carcass, and circulating metabolic hormones in beef heifers fed a diet high in linoleic acid beginning at four months of age J Anim Sci, January 1, 2003; 81(1): 261 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Giesy, M. A. McGuire, B. Shafii, and T. W. Hanson Effect of Dose of Calcium Salts of Conjugated Linoleic Acid (CLA) on Percentage and Fatty Acid Content of Milk Fat in Midlactation Holstein Cows J Dairy Sci, August 1, 2002; 85(8): 2023 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. de Boer Protection by Dietary Compounds against Mutation in a Transgenic Rodent J. Nutr., November 1, 2001; 131(11): 3082S - 3086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O'Rourke, J. C Stanley, U. Ravnskov, and T. Marshall VAT and fat BMJ, May 27, 2000; 320(7247): 1469 - 1469. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
