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1 Nestec Limited, Nestlé Research Centre, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland
The purpose of this study was to determine the effect of a fermented milk product containing Lactobacillus johnsonii La1 (formerly known as Lactobacillus acidophilus La1) on the phagocytic activity of peripheral blood leukocytes in healthy adult volunteers. Furthermore, we sought to define the effective doses of the bacteria, examine the effect on respiratory burst activity, and, finally, examine the contribution made by the starter culture to the biological effects. Volunteers were randomly distributed among three groups; each subject received one pot (150 ml) of fermented milk each day for 3 wk. The first two groups received a freshly prepared product fermented by Streptococcus thermophilus (group A) alone or S. thermophilus and 107 cfu/ml L. johnsonii La1 (group B). Group C received a product stored for a period of 21 to 28 d and that contained S. thermophilus and 106 cfu/ml of L. johnsonii La1.
Ingestion of L. johnsonii La1 did not significantly increase fecal lactobacilli counts. However, L. johnsonii La1 was able to survive intestinal transit and was only recovered from the feces of the volunteers of groups B and C. The fermented base alone showed a weak effect on respiratory burst but not on phagocytic activity. However, the product containing 107 cfu/ml L. johnsonii La1 significantly enhanced both functions. The product containing 106 cfu/ml of L. johnsonii La1 had no significant effect on either function. These results suggest that fecal persistence may not necessarily reflect in vivo colonization and may not be a prerequisite for all forms of immune reactivity.
Key Words: lactic acid bacteria • dose response • phagocytosis • respiratory burst
Submitted on March 2, 1998
Accepted on December 22, 1998
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