JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 82 No. 12 2582-2588
© 1999 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, J. L.
Right arrow Articles by Smith, K. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, J. L.
Right arrow Articles by Smith, K. L.

Efficacy of Intramammary Immunization with an Escherichia coli J5 Bacterin

J. L. Smith 1, J. S. Hogan 1, and K. L. Smith 1

1 Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster 44691

Intramammary immunization was investigated as a procedure to reduce the clinical signs of coliform mastitis. Twenty-four cows were equally distributed to the following Escherichia coli J5 immunization schedules: 1) Subcutaneous injection 14 d prior to the end of lactation, intramammary immunization 7 d after drying off, and subcutaneous injection 30 d into the dry period; 2) subcutaneous injections at drying off, at 30 d into the dry period, and within 12 h after calving; and 3) unimmunized controls. Intramammary immunizations were the infusion of vaccine via the teat canal into each of the four mammary glands. Cows were challenged by infusion of E. coli 727 into one uninfected mammary quarter at approximately 30 d after calving. Intramammary immunization enhanced antibody titers against E. coli J5 and E. coli 727 compared with subcutaneous immunization. Immunoglobulin G titers against E. coli J5 and E. coli 727 in whey were greater at the time of challenge and 7 d after challenge for cows that received the intramammary immunization than for cows immunized by only subcutaneous injections. Serum IgG titers against E. coli 727 were enhanced at 7 d after challenge for cows receiving intramammary immunizations compared with conventionally immunized cows. Serum IgM titers against E. coli 727 were higher at calving for cows receiving intramammary immunization compared with conventionally immunized cows. Immunization schedule had minimal effect on systemic and local signs of clinical mastitis following challenge.

Key Words: intramammary immunization • Escherichia coli J5 • mastitis • vaccine

Submitted on June 21, 1999
Accepted on August 13, 1999




This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
J. Detilleux, F. Vangroenweghe, and C. Burvenich
Mathematical Model of the Acute Inflammatory Response to Escherichia coli in Intramammary Challenge.
J Dairy Sci, September 1, 2006; 89(9): 3455 - 3465.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
J. S. Hogan, V. B. Cannon, K. L. Smith, C. Rinehart, and S. Miller
Effects of Adjuvants on Safety and Efficacy of an Escherichia coli J5 Bacterin
J Dairy Sci, February 1, 2005; 88(2): 534 - 542.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Dairy Science Association ®.