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1 Aurora Dairy Corporation, 3830 SW 38th Street, Gainesville, FL 32608
2 Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32610
3 Institute of Food and Agricultural Sciences Department of Statistics, University of Florida, Gainesville 32610
4 USDA-ARS, Food Animal Protection Research Laboratory, College Station, TX 77845
Holstein cows (n = 51) that had been diagnosed with toxic puerperal metritis were used to determine the treatment efficacy of various antibiotics. On the day of diagnosis, cows affected with toxic puerperal metritis were assigned randomly to three treatment groups. Cows in groups 1 and 2 received 22,000 IU/kg of procaine penicillin G i.m. for 5 d. In addition, cows in group 2 received an intrauterine infusion of 6 g of oxytetracycline on d 1, 3, and 5. Cows in group 3 received 2.2 mg/kg of ceftiofur sodium i.m. for 5 d. Dependent variables used to determine antibiotic efficacy included milk yield on d 1 through 12, rectal temperature on d 1 through 5, and serum haptoglobin concentration on d 1, 3, and 5. No difference was observed among groups for milk yield on d 1 and 12 or for temperature on d 1 and 5. Serum haptoglobin was elevated to > 10 mg/dl for cows in all groups; however, no difference was observed among groups on d 1 and 5. Because all groups showed a favorable response, this study suggests that there is no difference in treatment efficacy among antibiotics used to treat cows affected with toxic puerperal metritis.
Key Words: toxic puerperal metritis • cow • antibiotic • haptoglobin
Submitted on September 15, 1997
Accepted on February 17, 1998
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