| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Dairy Science, University of Wisconsin, Madison 53706
The accumulation of triglycerides in the liver has been associated with reduced hepatic function; however, direct evidence that fat accumulation causes decreased liver function is lacking. Hepatocyte monolayers isolated from ruminating calves with an initial low triglyceride concentration were either loaded or not loaded with triglycerides by incubation with 1.5 or 0 mM exogenous nonesterified fatty acids from 12 to 48 h after plating. Basal rates of synthesis of albumin and protein were not affected by triglycerides in the cell. Inclusion of insulin and glucagon from 12 to 72 h after plating increased rates of albumin and protein synthesis. Hepatocytes loaded with triglycerides were less sensitive to the hormonal stimulation of albumin and protein synthesis than were normal hepatocytes. Insulin clearance rates were also lower in hepatocytes loaded with triglycerides than in normal hepatocytes. Decreased insulin clearance and hormonal control of protein synthesis could contribute to the etiology of metabolic disorders that are associated with periparturient fatty liver in dairy cows.
Key Words: bovine • triglyceride • liver • hormone
Submitted on January 21, 1997
Accepted on October 6, 1997
This article has been cited by other articles:
|
|
 |
|
  A. Kotronen and H. Yki-Jarvinen Fatty Liver: A Novel Component of the Metabolic Syndrome Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 27 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kotronen, S. Vehkavaara, A. Seppala-Lindroos, R. Bergholm, and H. Yki-Jarvinen Effect of liver fat on insulin clearance Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1709 - E1715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kotronen, J. Westerbacka, R. Bergholm, K. H. Pietilainen, and H. Yki-Jarvinen Liver Fat in the Metabolic Syndrome J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3490 - 3497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Cooke, N. S. Del Rio, D. Z. Caraviello, S. J. Bertics, M. H. Ramos, and R. R. Grummer Supplemental Choline for Prevention and Alleviation of Fatty Liver in Dairy Cattle J Dairy Sci, May 1, 2007; 90(5): 2413 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oikawa and G. R. Oetzel Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis. J Dairy Sci, August 1, 2006; 89(8): 2999 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bobe, J. W. Young, and D. C. Beitz Invited Review: Pathology, Etiology, Prevention, and Treatment of Fatty Liver in Dairy Cows J Dairy Sci, October 1, 2004; 87(10): 3105 - 3124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tiikkainen, A.-M. Hakkinen, E. Korsheninnikova, T. Nyman, S. Makimattila, and H. Yki-Jarvinen Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes Diabetes, August 1, 2004; 53(8): 2169 - 2176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Hamel, J. L. Upward, and R. G. Bennett In Vitro Inhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A Thioesters Endocrinology, June 1, 2003; 144(6): 2404 - 2408. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
