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Journal of Dairy Science Vol. 81 No. 11 2866-2873
© 1998 by American Dairy Science Association ®
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Efficacy of Monensin for the Prevention of Subclinical Ketosis in Lactating Dairy Cows

T. F. Duffield 1, D. Sandals 1, K. E. Leslie 1, K. Lissemore 1, B. W. McBride 1, J. H. Lumsden 1, P. Dick 2, and R. Bagg 2

1 University of Guelph, Guelph, ON, Canada N1G 2W1
2 Provel, a Division of Eli Lilly Canada, Inc., Research Park Centre, Guelph, ON, Canada N1G 4T2

A total of 1010 dry cows and pregnant heifers was randomly selected from 25 dairy farms near Guelph, Ontario, Canada to receive either a controlled-release capsule of monensin or a placebo at 3 wk prior to expected calving. Serum samples were obtained at the time of treatment administration, and both serum and milk samples were collected at wk 1, 2, 3, 6, and 9 postcalving. The threshold used to define subclinical ketosis was selected a priori at a concentration of ge1200 µmol/L of ß-hydroxybutyrate. Using this threshold, the prevalence and incidence of subclinical ketosis were significantly reduced (50%) by monensin treatment. The duration of subclinical ketosis for cows that had been treated with monensin was also shorter than that for cows treated with the placebo. Monensin treatment significantly reduced the incidence of subclinical ketosis when the threshold was defined using higher concentrations of serum ß-hydroxybutyrate (1400 and 2000 µmol/L). In addition, monensin significantly reduced the prevalence of positive milk ketone tests.

Key Words: monensin • dairy cows • subclinical ketosis • ßbeta;-hydroxybutyrate

Submitted on October 6, 1997
Accepted on July 6, 1998




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