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Journal of Dairy Science Vol. 80 No. 9 1959-1964
© 1997 by American Dairy Science Association ®
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Isolation and Structural Identification of Bifidogenic Growth Stimulator Produced by Propionibacterium freudenreichii

Hiroharu Mori 1, Yoshio Sato 2, Naoki Taketomo 2, Tomonori Kamiyama 2, Yoshihiro Yoshiyama 2, Sachiko Meguro 1, Hiroko Sato 1, and Tsutomu Kaneko 1

1 Central Research Institute, Meiji Milk Products Co., 1-21-3 Sakae-cho, Higashimurayama, Tokyo 189, Japan
2 Health Science Research Institute, Meiji Milk Products Co., 540 Naruda Odawara, Kanagawa 250, Japan

A bifidogenic growth stimulator produced by Propionibacterium freudenreichii was purified, and its chemical structure was determined. We obtained 7.1 mg of a bifidogenic growth stimulator from 1738 g of lyophilized P. freudenreichii cells by silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The mass of the bifidogenic growth stimulator was 217.037 (C11H7NO4)as determined by high resolution mass spectrometry. Various experimental analyses indicated that the chemical structure of the bifidogenic growth stimulator was 2-amino-3-carboxy-1,4-naphthoquinone.

Key Words: bifidogenic growth stimulator • Propionibacterium freudenreichii • 2-amino-3-carboxy-1,4-naphthoquinone

Submitted on March 11, 1996
Accepted on March 17, 1997




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[Abstract] [Full Text] [PDF]


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