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Journal of Dairy Science Vol. 80 No. 2 318-323
© 1997 by American Dairy Science Association ®
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Efficacy of Cefquinome for Treatment of Cows with Mastitis Experimentally Induced Using Escherichia coli

N. Y. Shpigel 1, D. Levin 1, M. Winkler 2, A. Saran 2, G. Ziv 2, and A. Böttner 3

1 The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
2 The Kimron Veterinary Institute, Bet Dagan 50250, Israel
3 Hoechst Veterinar GmbH, Wiesbaden 65203, Germany

The efficacy of intramuscularly and intramammarily administered cefquinome was evaluated in experimental Escherichia coli mastitis in dairy cows. Forty-seven multiparous, Israeli Holstein cows in early lactation that produced at least 25 L/d of milk were used, and 400 to 750 cfu of E. coli were infused into two healthy quarters of each cow. Cows were randomly assigned to one of the following treatment groups: 1) 75 mg of cefquinome administered intramammarily three times at 12-h intervals, 2) 75 mg of cefquinome administered intramammarily three times at 12-h intervals and 1 mg/kg of cefquinome administered intramuscularly two times at a 24-h interval, 3) 1 mg/kg of cefquinome administered intramuscularly two times at a 24-h interval, and 4) 75 mg of ampicillin and 200 mg of cloxacillin administered intramammarily three times at 12-h intervals. All cows developed typical signs of acute clinical mastitis by 12 to 16 h postinoculation. Parenteral cefquinome therapy, with or without intramammary cefquinome (groups 2 and 3), significantly improved clinical recovery and return to milk production.

The bacteriological cure rates were considerably and significantly higher for cows in the groups treated with cefquinome than for cows in the group treated with ampicillin and cloxacillin. This study supported the efficacy of cefquinome in the treatment of clinical coliform mastitis in dairy cows.

Key Words: mastitis • therapy • cefquinome • Escherichia coli

Submitted on April 11, 1996
Accepted on July 25, 1996




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Copyright © 1997 by the American Dairy Science Association ®.