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Journal of Dairy Science Vol. 79 No. 9 1537-1542
© 1996 by American Dairy Science Association ®
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Regulation of the Gene Expression of Glucose Transporter in Liver and Kidney of Lactating Cows by Bovine Growth Hormone and Bovine Growth Hormone-Releasing Factor

F.-Q. Zhao 1, J. J. Kennelly 1, W. M. Moseley 2, and H. A. Tucker 3

1 Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5
2 The Upjohn Company, Kalamazoo, MI 49001
3 Department of Animal Science, Michigan State University, East Lansing 48824

Our objective was to study the effects of recombinant bovine growth hormone and bovine growth hormone-releasing factor on gene expression of glucose transporters in the liver and kidney of lactating cows. Primiparous cows received 29 mg/d of bovine growth hormone or 12 mg/d of bovine growth hormone-releasing factor by continuous intravenous infusion or no treatment (control) from 118 to 181 d postpartum. Growth hormone or growth hormone-releasing factor did not influence the mRNA abundance of the liver-type glucose transporter in the liver or kidney. Similarly, neither growth hormone-releasing factor nor growth hormone altered the mRNA abuindance of the erythrocyte-type or the intestinal-type glucose transporter in the kidney, but large individual differences were observed in the mRNA abundance of the intestinal-type glucose transporter in liver.

Key Words: growth hormone • growth hormone-releasing factor • glucose transporter • gene expression

Submitted on May 1, 1995
Accepted on March 1, 1996




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F.-Q. Zhao and A. F. Keating
Expression and Regulation of Glucose Transporters in the Bovine Mammary Gland
J Dairy Sci, June 1, 2007; 90(13_suppl): E76 - E86.
[Abstract] [Full Text] [PDF]


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