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of Cows in Response to Recombinant Interferon-
1 Department of Dairy and Poultry Sciences, University of Florida, Gainesville 32611
2 Department of Animal Sciences, University of Missouri, Columbia 65211
3 Department of Animal Science, Texas A & M University, College Station 77843
Two experiments tested the effect of recombinant ovine and bovine interferon- on corpus luteum lifespan, interestrous interval, and oxytocin-induced uterine secretion of prostaglandin F2
. Cows received intrauterine injections of 100 µg of recombinant ovine interferon- plus 1.4 mg of BSA or of 1.5 mg of BSA alone in Experiment 1 and 200 µg of recombinant bovine interferon- plus 1.3 mg of BSA or 1.5 mg of BSA alone in Experiment 2. Twice daily injections (0700 and 1900 h) were split evenly between the uterine horns from d 14 to 24 of the experimental estrous cycle via an AI pipette in Experiment 1 and via intrauterine catheters in Experiment 2. On d 17, cows were injected with 100 IU of oxytocin, and plasma was collected for analysis of 13,14-dihydro-15-keto-prostaglandinF2. Recombinant ovine interferon- extended the lifespan of the corpus luteum (27.5 vs. 19.2 d) and interestrous interval (30.5 vs. 20.6 d) and abolished the oxytocin-induced increase in 13,14-dihydro-15-keto-prostaglandinF2, which peaked at 30 min for the BSA control group (210.8 pg/ml). Recombinant bovine interferon- also extended the lifespan of the corpus luteum (29.0 vs. 21.4 d) and interestrous interval (31.5 vs. 22.6 d) and abolished the oxytocin-induced increase in 13,14-dihydro-15-keto-prostaglandin F2, which peaked at 30 min for the BSA control group (205.6 pg/ml). In conclusion, recombinant ovine interferon- and recombinant bovine interferon- were effective antiluteolytic agents in cattle.
Key Words: bovine • corpus luteum • interferon • progesterone
Submitted on January 3, 1995
Accepted on May 1, 1995
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