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Journal of Dairy Science Vol. 78 No. 7 1470-1476
© 1995 by American Dairy Science Association ®
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Effect of Bovine Interferon-tau on Body Temperature and Plasma Progesterone Concentrations in Cyclic Dairy Cows

M. D. Meyer 1, P. J. Hansen 1, W. W. Thatcher 1, M. Drost 2, and R. M. Roberts 3

1 Department of Dairy and Poultry Sciences, University of Florida, Gainesville 32611-0920
2 Large Animal Clinical Sciences, College of Veterinary Medicine, Gainesville 3261 14136
3 Department of Animal Sciences, University of Missouri, 158 Animal Sciences Research Center, Columbia 65211

We examined the effect of intramuscular injections of recombinant bovine interferon-tau on basal body temperature and plasma concentrations of progesterone in cows. Six mature, nonlactating Holstein cows were synchronized for estrus and assigned randomly to a replicated 3 x 3 Latin square design to receive 0, 1, or 5 mg of recombinant bovine interferon-tau intramuscularly on d 9, 12, or 15 of the estrous cycle. Rectal temperatures were measured, and blood was collected just prior to injection, at hourly intervals for 8 h, and at 10 and 12 h after injection. Treatment with 1 and 5 mg of recombinant bovine interferon-tau caused a rise in body temperature that peaked at 6 h (39.5 ± .13°C) and 4 h (40.3 ± .13°C), respectively. Analysis of homogeneity of regression for response curves indicated that 5 mg of recombinant bovine interferon-tau decreased plasma progesterone concentrations. This effect was not detected 6for the 1-mg dose of recombinant bovine interferon-tau. Intramuscular administration of 5 mg of recombinant bovine interferon-tau caused a hyperthermic response that was temporally associated with the decrease in plasma progesterone. Intramuscular administration of 1 mg of recombinant bovine interièron-tau caused a slight rise in temperature occurring 4 h later than that caused by 5 mg of recombinant bovine interferon-tau, and no decrease in plasma progesterone was detected. Recombinant bovine interferon-tau, administered at a 1-mg dose, warrants further study to determine whether it will alter survival rate of cattle embryos.

Key Words: interferon-tau • hyperthermia • progesterone

Submitted on December 7, 1994
Accepted on February 22, 1995




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