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Journal of Dairy Science Vol. 78 No. 4 825-831
© 1995 by American Dairy Science Association ®
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Ornithine-delta-Aminotransferase in Lactating Bovine Mammary Glands

J. J. Basch 1, E. D. Wickham 1, H. M. Farrell Jr. 1, and J. E. Keys 2

1 Agricultural Research Service, USDA, Eastern Regional Research Center, 600 East Mermaid Lane, Philadelphia, PA 19118
2 Agricultural Research Service, USDA, Beltsville Agricultural Research Center, Beltsville, MD 20705

The Occurrence and subcellular distribution of ornithine-delta-aminotransferase have been studied in lactating bovine mammary glands. The enzyme is localized in the mitochondria and has a unique thermal reaction profile that distinguishes it from putative liver and kidney isozymes. The enzyme concentration in the gland correlates well with a role in the conversion of ornithine into the proline precursor, L-Delta1-pyrroline-5-carboxylate. However, an unusually high Michaelis constant for the mitochondrial enzyme (8.4 mM) raises the question of enzyme efficiency in vitro such that this pathway needs to be considered in estimating barriers to protein secretion into milk.

Key Words: milk secretion • enzymes • proline

Submitted on August 11, 1994
Accepted on November 18, 1994






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Copyright © 1995 by the American Dairy Science Association ®.