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Journal of Dairy Science Vol. 78 No. 3 484-490
© 1995 by American Dairy Science Association ®
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Effect of Individual Caseins on Plasminogen Activation by Bovine Urokinase-Type and Tissue-Type Plasminogen Activators

I. Politis 1, J. H. White 1, B. Zavizion 1, J. J. Goldberg 1, M. R. Guo 1, and P. Kindstedt 1

1 Department of Animal and Food Sciences, University of Vermont, Burlington 05405

The effect was examined of individual caseins on the rate of plasminogen activation by bovine urokinase-type and tissue-type plasminogen activators. All individual caseins (alpha-CN. ß-CN, and kappa-CN) enhanced the activity of both types of plasminogen activators. Optimal concentrations for alpha-CN and ß-CN were 5 and 25 µg/ml, respectively. The enhancement of enzymatic activity declined when concentrations of alpha-CN and ß-CN were higher. In contrast, increasing concentrations of kappa-CN from 0 to 200 µg/ml resulted in corresponding increases in activity of both types of plasminogen activators. On a weight basis, alpha-CN was the most effective enhancer of plasminogen activator activity. Indirect evidence obtained with experiments utilizing alpha-CN immobilized on agarose suggested that the effect is related to extensive binding of plasminogen and both types of plasminogen activators to casein.

Key Words: plasminogen activator • casein

Submitted on May 23, 1994
Accepted on December 9, 1994




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B. Ismail, L. H. Choi, L. M. Were, and S. S. Nielsen
Activity and nature of plasminogen activators associated with the casein micelle.
J Dairy Sci, September 1, 2006; 89(9): 3285 - 3295.
[Abstract] [Full Text] [PDF]


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Copyright © 1995 by the American Dairy Science Association ®.