JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 78 No. 11 2388-2394
© 1995 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goff, J. P.
Right arrow Articles by Horst, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goff, J. P.
Right arrow Articles by Horst, R. L.

Milk Fever and Dietary Cation-Anion Balance Effects on Concentration of Vitamin D Receptor in Tissue of Periparturient Dairy Cows

J. P. Goff 1, T. A. Reinhardt 1, and R. L. Horst 1

1 USDA, Agricultural Research Service, National Animal Disease Center, Metabolic Diseases and Immunology Research Unit, Ames, IA 50010-0070

Milk fever is the clinical disease associated with severe hypocalcemia in dairy cows. In this experiment, we tested the hypothesis that calcium homeostasis is a result of a decreased concentration of receptors for 1,25-dihydroxyvitamin D in the tissues of cows that develop milk fever. Samples of colon mucosa were obtained for analysis of vitamin D receptor concentration in a longitudinal study of Jersey cows during the 2 wk before and after parturition. In the first study, 21 cows fed an alfalfa hay diet were biopsied every 3rd d from 2 wk before to 2 wk after calving. The concentration of vitamin D receptor in the colon during late gestation was three- to fourfold higher than the concentration of vitamin D receptor in the colon mucosa in nonpregnant cows (90 ± 8 vs. 26 ± 5 fmol/mg of protein). At parturition, colon concentration of vitamin D receptor decreased to 66 ± 7.5 fmol/mg of protein. During early lactation, concentrations of vitamin D receptor in the colon were similar to precalving concentrations. There was no significant difference of concentrations of vitamin D receptor in the colon prior to calving, at calving, or in early lactation between cows that did develop milk fever and those that did not. Results were similar in a second study, in which 7 cows were fed a high cation alfalfa diet, and 6 cows were fed the same diet with anionic salts added. Those data do not support the hypothesis that decreased concentrations of vitamin D receptor prior to calving is a causative factor of milk fever within the Jersey breed. However, a decline of concentrations of vitamin D receptor in tissue at calving may reduce the ability of all cows to respond to the calcium demands of lactation.

Key Words: milk fever • cation-anion balance • vitamin D receptor

Submitted on March 20, 1995
Accepted on May 26, 1995




This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
A. Rizzo, G. Minoia, E. Ceci, R. Manca, M. Mutinati, M. Spedicato, and R. L. Sciorsci
The Effect of Calcium-Naloxone Treatment on Blood Calcium, {beta}-Endorphin, and Acetylcholine in Milk Fever
J Dairy Sci, September 1, 2008; 91(9): 3454 - 3458.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Dairy Science Association ®.