JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 78 No. 10 2208-2220
© 1995 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Den Top, A. M.
Right arrow Articles by Beynen, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Den Top, A. M.
Right arrow Articles by Beynen, A. C.

Time Trends of Plasma Lipids and Enzymes Synthesizing Hepatic Triacylglycerol During Postpartum Development of Fatty Liver in Dairy Cows

A. M. Van Den Top 1, T. Wensing 1, M.J.H. Geelen 1, G. H. Wentink 1, A. T. Van't Klooster 1, and A. C. Beynen 1

1 Department of Large Animal Medicine and Nutrition and Laboratory of Veterinary Biochemistry, Faculty of Veterinary Medicine, Utrecht University, PO Box 80,152, 3508 TD Utrecht, The Netherlands

We studied development of fatty liver in high producing dairy cows with free access to feed during the dry period and thus showed the combined effects of parturition and prepartum overfeeding. Postpartum liver triacylglycerol concentrations at 1 wk postpartum, as measured in liver biopsies, had increased more than 6-fold, which was preceded or accompanied by an increase in plasma NEFA concentrations. Concentrations of hepatic phospholipid changed only slightly. The amounts of total lipids in serum, very low density lipoproteins, and high density lipoproteins significantly decreased by .5 wk after parturition, and concentrations of high density lipoproteins rose steadily. The pattern was similar for concentrations of total cholesterol and phospholipid in serum. Total lipid concentrations in low density lipoproteins were not altered after parturition. The activity of microsomal phosphatidate phosphohydrolase in the liver showed a transient increase at .5 wk after calving, but activity of microsomal glycerolphosphate acyltransferase remained relatively constant. The activities of diacylglycerol acyltransferase had increased about twice at 1 wk after calving and remained at this high level until at least 4 wk after parturition. The rise in activity of diacylglycerol acyltransferase was probably a response to the extra influx of fatty acids to channel them into triacylglycerol. Activities of microsomal cholinephosphate cytidylyltransferase initially increased after calving and then decreased slightly. Activities of hepatic choline kinase had increased after calving. This study indicates that hepatic triacylglycerol accumulates because of the increased hepatic uptake of NEFA and the simultaneous increase in activity of diacylglycerol acyltransferase.

Key Words: dairy cows • fatty liver • dry period • glycerolipid synthesis

Submitted on January 10, 1995
Accepted on May 4, 1995




This article has been cited by other articles:


Home page
 J DAIRY SCIHome page
A. T. M. van Knegsel, H. van den Brand, J. Dijkstra, W. M. van Straalen, R. Jorritsma, S. Tamminga, and B. Kemp
Effect of Glucogenic vs. Lipogenic Diets on Energy Balance, Blood Metabolites, and Reproduction in Primiparous and Multiparous Dairy Cows in Early Lactation
J Dairy Sci, July 1, 2007; 90(7): 3397 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
A. T. M. van Knegsel, H. van den Brand, E. A. M. Graat, J. Dijkstra, R. Jorritsma, E. Decuypere, S. Tamminga, and B. Kemp
Dietary Energy Source in Dairy Cows in Early Lactation: Metabolites and Metabolic Hormones
J Dairy Sci, March 1, 2007; 90(3): 1477 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
G. N. Douglas, T. R. Overton, H. G. Bateman II, H. M. Dann, and J. K. Drackley
Prepartal plane of nutrition, regardless of dietary energy source, affects periparturient metabolism and dry matter intake in Holstein cows.
J Dairy Sci, June 1, 2006; 89(6): 2141 - 2157.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
R. A. Nafikov, B. N. Ametaj, G. Bobe, K. J. Koehler, J. W. Young, and D. C. Beitz
Prevention of Fatty Liver in Transition Dairy Cows by Subcutaneous Injections of Glucagon
J Dairy Sci, May 1, 2006; 89(5): 1533 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
D. Tedesco, A. Tava, S. Galletti, M. Tameni, G. Varisco, A. Costa, and S. Steidler
Effects of Silymarin, a Natural Hepatoprotector, in Periparturient Dairy Cows
J Dairy Sci, July 1, 2004; 87(7): 2239 - 2247.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
S. C. L. Van Winden, R. Jorritsma, K. E. Muller, and J. P. T. M. Noordhuizen
Feed Intake, Milk Yield, and Metabolic Parameters Prior to Left Displaced Abomasum in Dairy Cows
J Dairy Sci, April 1, 2003; 86(4): 1465 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
C. T. Westwood, I. J. Lean, and J. K. Garvin
Factors Influencing Fertility of Holstein Dairy Cows: A Multivariate Description
J Dairy Sci, December 1, 2002; 85(12): 3225 - 3237.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American Dairy Science Association ®.