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Journal of Dairy Science Vol. 77 No. 8 2272-2280
© 1994 by American Dairy Science Association ®
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Effect of Re-17 Mutant Salmonella typhimurium Bacterin Toxoid on Clinical Coliform Mastitis

Alyn M. McClure 1, Edward E. Christopher 1, W. A. Wolff 2, W. H. Fales 2, Gary F. Krause 2, and Joe Miramonti 2

1 Herd Health Management, Gilbert, AZ 85234-0809
2 University of Missouri, Columbia 65211

The objective of this study was to test the hypothesis that the incidence and severity of clinical coliform mastitis could be decreased by Re-17 mutant Salmonella typhimurium bacterin toxoid. Holstein-Friesian cows from two Arizona dairies were selected for this study based on July through November projected calving dates; peak lactation occurred during the period of highest rainfall and peak environmental stress. The cows were randomly assigned to either a vaccinate or a control group, and 1292 cows were paired by herd, parity, calving date, and milk yield. The 646 vaccinates were injected twice during the third trimester of pregnancy with an Re-17 mutant S. typhimurium bacterin toxoid, and the 646 controls were not vaccinated. Vaccinated cows had significantly fewer clinical cases of coliform mastitis with positive coliform cultures and had lower culling rate from coliform mastitis than control cows during the first 5 mo of lactation. During the same period, the mortality rate from clinical coliform mastitis was 75% less in the vaccinated clinical coliform mastitic group than in the control group. Incidence of mastitis increased with advancing parity. The Re-17 mutant Salmonella typhimurium bacterin toxoid provided cross-protection against coliform mastitis; incidence and severity of clinical coliform mastitis were significantly lowered during the first 5 mo of lactation.

Key Words: core antigen • coliform • cross-protection • mastitis

Submitted on July 16, 1993
Accepted on March 11, 1994




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D. J. Wilson, Y. T. Grohn, G. J. Bennett, R. N. Gonzalez, Y. H. Schukken, and J. Spatz
Comparison of J5 Vaccinates and Controls for Incidence, Etiologic Agent, Clinical Severity, and Survival in the Herd Following Naturally Occurring Cases of Clinical Mastitis
J Dairy Sci, September 1, 2007; 90(9): 4282 - 4288.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American Dairy Science Association ®.