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Journal of Dairy Science Vol. 76 No. 9 2485-2492
© 1993 by American Dairy Science Association ®
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Augmentation of Macrophage Phagocytic Activity by Cell-Free Extracts of Selected Lactic Acid-Producing Bacteria

Glenn E. Hatcher 1 and Randall S. Lambrecht 1

1 Department of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee 53201

Oral and intraperitoneal administration of lactic acid-producing bacteria can significantly augment the immune response in murine models; however, the immunopotentiating effects in these studies differ significantly. Murine macrophagelike cell line J774 was cultured in the presence of cell-free extracts of Lactobacillus acidophilus and Bifidobacterium longum, and the effect on macrophage function was evaluated by measurement of synthesis of selected enzymes and their ability to take up either acrylamide particles or live Salmonella typhimurium. Lysozyme activity of J774 cells was significantly decreased by cell-free extracts of B. longum, but not of L. acidophilus, whereas extracts of both strains induced morphological changes and significantly enhanced phagocytosis of inert particles or viable Salmonella. Whole cell extracts of lactic acid-producing bacteria are therefore capable of altering macrophage function in a strain-dependent manner.

Key Words: Lactobacillus • macrophage • phagocytosis • probiotics

Submitted on October 5, 1992
Accepted on April 20, 1993




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