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1 Department of Cell Biology, Duke University Medical Center, and Durham Veterans Administration Medical Center, Durham, NC 27710
Peptide YY is released into the circulation after ingestion of a meal, a response that is markedly enhanced in patients with malabsorption. The enhanced release of peptide YY slows gastric emptying and transit of meals through the small intestine. The net effect is increased efficiency of digestion and absorption of nutrients. Once the efficiency of nutrient utilization is optimized and the delivery of unabsorbed nutrients to the distal gut decreased, peptide YY release is inhibited. As peptide YY slows colonic transit, it could also improve salvage of unabsorbed nutrients by enhancing bacterial production of volatile fatty acids and their subsequent absorption by the colonic mucosa.
Key Words: peptide YY • endocrine control • digestion • gastrointestinal tract
Submitted on June 22, 1992
Accepted on January 27, 1993
This article has been cited by other articles:
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  K. Kawakubo, H. Yang, and Y. Tache Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats Am J Physiol Gastrointest Liver Physiol, November 1, 2002; 283(5): G1035 - G1041. [Abstract] [Full Text] [PDF]
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H. Yang, K. Kawakubo, and Y. Tache Intracisternal PYY increases gastric mucosal resistance: role of cholinergic, CGRP, and NO pathways Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G555 - G562. [Abstract] [Full Text] [PDF]
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